Study On The Correlation Of Serum Lp-PLA2 In Postmenopausal Patients With Type 2 Diabetes Mellitus

Objective:To investigate serum Lipoprotein-associated phospholipase A2(Lp-PLA2)among postmenopausal women with Type 2 diabetes mellitus(T2DM)and the related influencing factors.Methods:A group of 80 postmenopausal women with T2 DM patients(case group) with an average age of 57.65±4.28 years and a group of 80 normal postmenopausal women(control group)with an average age of 57.30±4.29 years were recruited from January 2018 to November 2018.The Lp-PLA2 levels of blood serum was determined by ELISA method.And we analyzed and compared the correlations between serum Lp-PLA2 levels and blood lipid,fasting blood glucose(FBG),systolic blood pressure(SBP),diastolic blood pressure(DBP),alanine aminotransferase (ALT),aspartate aminotransferase(AST),albumin(ALB),blood urea nitrogen(BUN),creatinine(CRE)in the two groups were analyzed and compared.Results:Levels of Lp-PLA2,TG,TC,LDL-C,FBG and TG/HDL-C in case group were statistically significantly higher than those in control group(P<0.05).By using Spearman’s rank correlation coefficient,the levels of Lp-PLA2 were positively correlated with levels of TC and LDL-C(P<0.05)and negatively correlated with levels of HDL-C(P<0.05).Logistic regression analysis showed that T2 DM and TC were associated with elevated levels of Lp-PLA2.Conclusion:1 The levels of serum Lp-PLA2 in postmenopausal T2 DM patients were higher than those in case group,and T2 DM and TC were associated with elevated levels of Lp-PLA2.2 It is suggested that the elevated level of Lp-PLA2 may be one of the reasons that lead to more cardiovascular events in postmenopausal diabetic patients.