Study On The Relationship Between Combined Detection Of S100B, IL-1B, IL-6 And The Diagnosis And Prognosis Of Craniocerebral Injury In Young Adults

Objective:To explore the sensitivity of combined detection of S100B,IL-1B,IL-6 in serum and cerebrospinal fluid of young adults with traumatic brain injury（TBI）to assist in TBI diagnosis and prognosis evaluation.Methods:132 cases of young TBI patients who were treated in ICU Ward after neurosurgical surgery in our hospital were selected as observation group（35 light cases,55medium cases and 42 heavy cases）,and 50 young adults who admitted in the hospital without TBI and cerebrospinal fluid puncture is needed during the same period of physical examination were selected as the control group.Observing patients’clinical manifestation,such as Glagow Coma Score.The contents of S100B,IL-1B and IL-6 in serum and cerebrospinal fluid were determined by the method of enzyme-linked immunosorbent assay（ELISA）.ROC curve was used to analyze the diagnostic value of S100B combined with IL-1B and IL-6 for TBI.We used SPSS19.0 and the data were expressed by`x±s,and P<0.05 were considered to be statistically significant.Results:（1）the contents of S100B,IL-1B and IL-6 in serum（F=8.351⁸.769,P<0.05）and cerebrospinal fluid（F=8.367⁸.967,P<0.05）of severe patients in the observation group were significantly higher than those in the control group;（2）there was a positive correlation between the contents of S100B,IL-1B and IL-6 in serum and CSF in the observation group(r _S100B=0.89,r_IL-1B=0.84,r_IL-6=0.83,P<0.05);（3）the area under the ROC curve of serum S100B,IL-1B,IL-6 and the combined detection and diagnosis of TBI was 0.810,0.758,0.703 and 0.922,respectively;（4）the expression levels of S100B,IL-1B and IL-6 in serum（F=8.671⁸.849,P<0.05）and cerebrospinal fluid（F=8.948⁹.371,P<0.05）of the observation group were negatively correlated with the prognosis of TBI in young adult.Conclusion:Serum and cerebrospinal fluid S100B,IL-1B and IL-6 are closely related to the disease condition and prognosis severity,and the combined diagnosis efficiency of the three is higher than that of the single test.