The Clinical Observation Of Female Overactive Bladder With Relieving Liver And Reinforcing Spleen And Tolterodine

ObjectiveObserve the effectiveness and safety of the method of relieving liver and reinforcing spleen combined with tolterodine on the treatment of female overactive bladder of the syndorome of liver-stagnation and spleen-deficiency,providing a new clinical treatment for the overactive bladder.MethodsBetween January 2018 and January 2019 in outpatient department of Guangdong Province Hospital of Integrated traditional Chinese and Western Medicine,female who are diagnosed with overactive bladder of the syndorome of liver-stagnation and spleen-deficiency,choosing a total of 68 patients who meets inclusion criteria were randomly assigned to two groups:patients in treatment group were instructed to take relieving liver and reinforcing spleen formulae liquid combined with tolterodine,and patients in control group only were instructed to taketolterodine.Two groups completed for 4 weeks of treatment.Let patients record urine Diaries 3 days before the beginning of treatment and 3 days after the end of the treatment.Based on the datas of the frequency of daytime urination and nocturnal urination、urgency and urge incontinence、mean urine volume average 24 hours、uroflowmetry and the scores of overactive bladder symptom score(OABSS)and quality of life questionnaire(QOL),which were calculated and analyzed before and after the treatment to evaluate the clinical effect.Results1.A total of 68 Patients entered the trial,data from 61 patients(31 treatment group and 30 For control group)which were available for the analysis of efficacy was defined as the full analysis.Compared to the baseline,both treatment group and control group resulted in a significant improvement in the frequency of daytime urination and urge incontinence、nocturnal urination average 24 hours、volume voided per micturiton、uroflowmetry and the scores of OABSS and QOL also significantly improved from it(P<0.01).2.After treatment course,the frequency of daytime urination average 24 hours、volume voided per micturiton、uroflowmetry and the difference values before and after treatment were statistically significant(P<0.05);the scores oF QOL was no statistical significance(P>0.05),but the difference values before and after treatment were statistically significant(P<0.05).3.After treatment course,the frequency of urge incontinence、nocturnal urination average 24 hours and the scores of OABSS and the difference values before and after treatment were no statistical significance(P>0.05).4.In terms of drug safety,Dry mouth adverse reaction was not seen,the adverse reaction incident was 9%in the treatment group,while the control group was 30%.Dry mouth was the most important adverse reaction,the incidence was 15%,the treatment group was significantly lower than the control group,but the adverse reaction were no statistical significance(P>0.05)ConclusionUsing relieving liver and reinforcing spleen combined with tolterodine to treatment of female overactive bladder of the syndorome of liver-stagnation and spleen-deficiency,can improve the lower urinary tract symptoms such as urgency and urge incontinence significantly better than the treatment of application of tolterodine purely.It have obvious advantage in reducing the incidence of adverse reaction and improving the patients quality of life,is a empound preparation safe and effective,and it is a new choice to treat this disease.