| Part Ⅰ Influencing factors associated with lumbar spine and femoral neck bone mineral density in population aged 50 years and older in SuzhouObjective:The objective of this study was to investigate the correlations between the gender-and body-site-specific factors and bone mineral density(BMD)at the lumbar spine and femoral neck in population aged≥50 years and older in Suzhou.Methods:A total of 2602 subjects who had undergone comprehensive routine health examinations in our hospital from January 2011 to December 2017 were enrolled in this study.The data of age,height,weight,waist circumference and blood pressure were collected,the BMD of lumbar spine and femoral neck was measured,and other biochemical markers and serum tumor markers were assayed.Results:Multiple linear regression analysis showed that age,waist circumference and ALP were the risk factors for the decline of bone mass in lumbar spine or femoral neck,while height,BMI and systolic blood pressure were protective factors.In addition,serum ferritin is an important risk factor for the decline of BMD in women over 50 years of age.Further logistics regression analysis showed that older age,low height,low BMI and high ALP level may increase the risk of osteopenia or osteoporosis in both men and women.Among women,high serum ferritin level was another important factor for osteoporosis.Conclusion:This study revealed the relationship between gender-and body-site-specific factors and BMD in people over 50 years old.The older age and high ALP are the risk factors of bone loss in both two genders,while height and BMI have certain protective effect on bone mass.At the same time,iron accumulation in postmenopausal women will further increase the risk of osteoporosis.Part Ⅱ Evaluation of iron status in healthy Chinese people and their age-related correlation to bone mineral densityObjective:This study aimed to evaluate iron status in healthy Chinese subjects in Suzhou area and investigate age-related relationships between body iron stores and bone mineral density.Methods:This cross-sectional study included 11,032 healthy Chinese subjects aged 16-90 years.Serum ferritin concentrations were measured by electrochemiluminescence immunoassay,and the changes in concentrations were calculated with respect to sex and age.Bone mineral densities(BMDs)of the lumbar spines and femur necks of 4,978 subjects were measured by dual-energy X-ray absorptiometry(DXA).The patterns of age-related BMD changes were visualized and correlations between serum ferritin levels and BMD were statistically analyzed in different age-stratified groups.Results:The medians(interquartile ranges)of serum ferritin were 123.01(77.64-200.50)ng/mL for men and 33.44(13.91-73.79)ng/mL for women.The concentrations of serum ferritin remained relatively stable in men and premenopausal women,while a dramatic change occurred in postmenopausal women.Based on the age-related trend of changes in serum ferritin concentrations,we categorized the subjects into three groups,namely ≤50 years,51-75 years,and≥76 years,for each sex and then analyzed the correlation between ferritin concentrations and BMD.Serum ferritin level was negatively correlated with BMD of the lumbar spines and femoral neck only in women in the 51-75-year age group(r=-0.108 and-0.082,respectively;P<0.001).Multiple regression analysis also showed that ferritin was an independent risk factor for bone loss in women aged 51-75 years.Furthermore,when we divided serum ferritin into quartiles,the odds for prevalent osteopenia and osteoporosis were 2.35-fold(95%CI=1.44-3.84)and 3.16-fold(95%CI=1.34-7.49)higher in women in the highest quartile,respectively,compared with those in the lowest quartile.Conclusion:This study has identified the association between iron accumulation and bone weakening.In addition,serum ferritin and BMD were significantly negatively correlated only in post-menopausal women in the 51-75-year age group but not in all post-menopausal age groups. |
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