Correlation Analysis Between High Density Lipoprotein Subclass And Coronary Stenosis

Objective: To investigate the correlation between high density lipoprotein(HDL)subclass and coronary artery stenosis in patients with coronary heart disease(CHD).Methods:(1)Fifty-three patients with suspected coronary heart disease admitted to the Department of Cardiology,Affiliated Hospital of Xiangnan University from March 2018 to September 2018 were selected.Coronary arteriography(CAG)was performed to determine the degree of coronary stenosis according to the results of coronary angiography.Thirty-eight patients with coronary heart disease(stenosis of at least one coronary artery or its branches > 50%)were diagnosed after CAG,including 25 males,13 females and 15 undiagnosed patients,including 5males and 10 females.(2)On the second day after admission,fasting venous blood was taken and the content of high density lipoprotein subclasses was determined by two-dimensional electrophoresis-immunoblotting assay.The Gensini score assessment method was used to evaluate the degree of coronary artery stenosis in patients undergoing coronary angiography.(3)Independent sample t-test and chi-square test were used to detect the difference between coronary heart disease group and non-coronary heart disease group.Linear regression correlation analysis was used to detect the correlation between high density lipoprotein subclass and coronary stenosis.Results:(1)BMI,low-density lipoprotein,total cholesterol,diabetes,hypertension,and smoking were lower in the non-coronary heart disease group than in the coronary heart disease group(P<0.05).The difference was statistically significant.The high-density lipoprotein and apolipoprotein A in the coronary heart disease group were lower than those in the non-coronary heart disease group(P<0.05),and the difference was statistically significant.(2)Preβ1-HDL,HDL3 b and HDL3 c were lower in the non-coronary heart disease group than in the coronary heart disease group(P<0.05),and HDL2 b was higher than that in patients with coronary heart disease(P<0.05).The difference was statistically significant.(3)Preβ1-HDL,HDL3 c,HDL3b were positively correlated with coronary stenosis,and HDL2 b was negatively correlated with coronary stenosis.Conclusion: High-density lipoprotein subclasses Preβ1-HDL,HDL3 c,and HDL3 b were positively correlated with coronary stenosis,and HDL2 b was negatively correlated with coronary stenosis.In clinical diagnosis and treatment,HDL2 b value may be used as a predictor of coronary heart disease.The influence of Preβ1-HDL,HDL3 b,HDL3c and HDL2 b values on the degree of coronary artery stenosis in the high-density lipoprotein subclass can provide an important reference for predicting coronary heart disease.