Clinical Study On The Treatment Of Postperative Mixed Hemorrhoids Using Compound Zanthoxylum-nitidum Sitz Bath Lotion Combined With Indomethacin Suppository

Objective: To explore the clinical efficacy about compound zanthoxylum-nitidum sitz bath lotion combined with indomethacin suppository in postoperative patients with mixed hemorrhoids.Methods:This study choose 144 patients as subjects who were diagnosed as mixed hemorrhoids(III~IV degree of internal hemorrhoids)and in First affiliate hospital of South China University from October 2018 to February 2019.The enrolled patients were divided into control group(n=48),test group 1(n=48)and test group 2(n=48)according to the random number method.All patients were given hemorrhoids milligant-morgant hemorrhoidectomy and procedure for prolapsed hemorrhoid(PPH),postoperative routine nursing and treatment.Control group was given potassium permanganate sitz bath on the next day after surgery,and test group 1 was given compound Zanthoxylum nitidum sitz bath lotion combined with indomethacin for anal embolization on the next day after surgery,test group 2 was given potassium permanganate sitz bath and indomethacin for anal embolization on the next day after surgery,and they were continuously treated for 2 courses as 7d for a course.The postoperative pain,postoperative hemorrhage,wound margin edema,anal pendant expansion and wound healing rate were observed.The differences of fibroblasts in the new granulation tissue were observed under microscope at 3d and 7d after surgery.The wound healing time,clinical efficacy,satisfaction and recurrence were compared between the two groups.Results:1.There were no significant differences in the gender,age,disease duration,disease grading,quantity of surgical incisions and preoperative pain VAS score among the groups(P>0.05),but they were comparable.2.The pain VAS score,hemorrhage score,wound margin edema score and anal pendant expansion score in test group 1 and test group 2 were significantly lower than those in control group at 3d,5d and 7d after surgery,and scores in test group 1 were significantly lower than those in test group 2(P<0.05).3.The quantity of wound fibroblasts in test group 1 and test group 2 was significantly higher than that in control group at 3d and 7d after surgery,and the quantity of wound fibroblasts in test group 1 was significantly higher than that in test group 2 at 3d and 7d after surgery(P<0.05).4.The wound healing rate in test group 1 and test group 2 was significantly higher than that in control group at 3d,5d and 7d after surgery(P<0.05).The wound healing rate in test group 1 was significantly higher than that in test group 2 at 3d,5d and 7d after surgery(P<0.05).5.The wound healing time in test group 1 and test group 2 was significantly lower than that in control group(P<0.05),and the wound healing time in test group 1 was lower than that in test group 2 [(17.45±2.31)d vs(19.64±2.69)d](P<0.05).6.The total effective rates in the groups all were 100%.There was no significant difference in the satisfaction among test group 1,test group 2 and control group[(3.46±0.48)points vs(3.18±0.69)points vs(P>0.05)(3.27±0.59)points ].Conclusions:1、 The treatment of postperative mixed hemorrhoids using compound zanthoxylum-nitidum sitz bath lotion combined with indomethacin suppository can evidently alleviate the postoperative pain,relieve the symptoms of wound margin edema,hemorrhage and anal pendant expansion,and effectively promote the proliferation of wound fibroblasts,facilitate the wound healing and accelerate the recovery of patients.2、This therapy is effective and safe,can be used as a fist-line treatment scheme at Proctolgy Department.