The Clinical Observation On Self-made ChaihuLiuwei Decoction In The Treatment Of Systemic Lupus Erythematosus With Depression Of Liver And Kidney Yin Deficiency

ObjectiveTo observe the efficacy and safety of self-made ChaihuLiuwei Decoction in the treatment of systemic lupus erythematosus(SLE)patients with depression of liver and kidney yin deficiency type,and to provide more effective treatment for SLE patients with depression,so as to give full play to the advantages of traditional Chinese medicine in the treatment of SLE.MethodsFrom April 2018 to December 2018,50 patients in rheumatism outpatient and inpatient departments of the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine were enrolled.The patients in the treatment group maintained their original western medicine treatment plan.The internal Chinese medicine treatment plan was self-made ChaihuLiuwei Decoction:Chaihu 10g,Dangshen 15g,Pinelliaternata 10g,Scutellariabaicalensis 10g,date 10g,cooked ground 20g,yam 20g,cornel meat 15g,DanPi 10g,Poriacocos 15g,Alisma 15g,ginger 5g,licorice 5g.(Decoction method:add 500ml water to each side,decoct gently for 45 minutes to 150 ml,one dose per day.)For 8 weeks,clinical symptoms,laboratory data,SLEDAI scores and 24 Hamilton Depression Scale(HAMD)scores were observed and recorded before and after treatment.The efficacy and safety of patients before and after treatment with self-made ChaihuLiuwei Decoction were observed.SPSS25.0 was used to analyze the data and draw conclusions.ResultsThe SLEDAI score,HAMD-24 score and TCM symptom score of the patients after taking the self-made ChaihuLiuwei Decoction for 8 weeks were all lower than before,and the difference was statistically significant(P<0.05).In the evaluation of curative effect of TCM symptoms,after 8 weeks of treatment,28 of 48 patients were effective,20 were ineffective,and the overall efficiency was 58.3%.After 8 weeks of treatment,according to the HAMD score reduction rate,the depressive symptoms of the patients were clinically alleviated in 1 case,markedly effective in 9 cases,effective in 17 cases and ineffective in 21 cases.The overall efficiency was 56.25%.After treatment,complement C3 and C4 could be increased(P<0.05),anti-ds-DNA titer could be reduced(P<0.05),and inflammatory indicators ESR and CRP could be reduced(P<0.05).In terms of safety indicators,after 8 weeks of treatment,WBC,HB,PLT in blood analysis had no significant difference compared with before treatment(P>0.05);liver function(ALT,AST)values had no significant difference compared with 0 weeks(P>0.05);the mean values of CREA and TG decreased after treatment,and the difference was statistically significant(P<0.05).ConclusionSelf-made ChaihuLiuwei Decoction can reduce SLEDAI score,HAMD-24 score and TCM syndrome score of patients with depression of liver-kidney Yin deficiency type,increase complement C3 and C4,decrease the titer of anti-ds-DNA,reduce creatinine value and triglyceride value,and has a certain clinical effect.There was no significant effect on leukocyte,hemoglobin,platelet and liver function(AST,ALT),no obvious gastrointestinal discomfort and allergic reaction,and the safety was good.