Academic Experience Of Professor Jinshi On SLE

Under the guidance of traditional Chinese medicine (TCM), based on the experience on systemic lupus erythematosus (SLE) of professor Jin Shi, with the thread of "kidney deficiency and stagnant toxin" , this paper explores the etiology , pathogenesis> differentiation and treatment of SLE, discusses the method of tonifying kidney and eliminating toxin and the clinical application of Langchuangjing Granule (LG), summarizes the clinical curative effect. Combined by experimental results, this paper probes the mechanism of LG on SLE with the respect of immuno-regulation. There are seven parts in this paper.The first part reviews the recognition of the name of SLE in ancient TCM literature. There is no corresponding name of SLE in literature, which is the name in modern medicine. Since it is difficult to name SLE with a single and exact one, the name depends on the course, attacking Zang-Fu organ and clinical manifestations.The second part deeply discusses the etiology and pathogenesis of SLE. Only exopathogen or internal injury is not enough to reflect the complication of SLE, both together are beneficial to grasp the etiology and pathogenesis of SLE. Although the manifestation of SLE are variable, the basic pathogenesis is still regular. This part elaborates supervisor's recognition of SLE from three aspects. 1:kidney-Yin deficiency is the Ben of SLE; 2:retaining of stagnant toxin is the B/ao of SLE; 3:kidney deficiency and stagnant toxin is the key of pathogenesis.Through the epidemiological survey on the treatment of SLE with TCM and differentiation of SLE, the third part puts forward that the syndrome of kidney deficiency and stagnant toxin is the major syndrome of active SLE, and that the method of tonifying kidney and eliminating toxin is the treatment principle of active SLE. This part discusses the symptom basis of kidney-deficiency and stagnant-toxin syndrome, explores the experimental foundation of the methodof tonifying kidney and eliminating toxin, probes the meaning of LG prescription and the function of major herbs. The clinical curative effect shows that LG and western medicine group is better than single western medicine group in improving symptoms, decreasing injury indices, improving abnormal laboratory examinations and antinuclear antibody lessening the attack of SLE, declining side-effects of western medicine and reducing the dosage of hormone.Through the summarization of experiments on BXSB mice and ICR mice, the forth part makes sure that LG has immunization on SLE animals, some of these experiments fill in the gaps in the field of SLE treated with TCM. The acute toxicity test of LG shows no apparent toxin and side-effect, which provides the evidence for declaring and exploiting new drug,The fifth and the sixth parts introduce the treatment experience of the supervisor on variable manifestations such as fever, arthralgia, erythema, xerostomia and xerophthalmia, lupoidnephritis, hepatic injury. And these two parts probe how the supervisor grasps SLE from aspects of the whole and the part, differentiation of syndromes and differentiation of diseases, macroscopic and microcosmic, analyze the characteristic of TCM and the advantage of western medicine, emphasize the combination of both.The reference includes some articles of the supervisor which are the complement to his academic ideas and the status quo of clinic and experiment research which helps to comprehend new trends, elucidate existent questions, prospect new trains of thought.