Clinical Observation Of Jiawei Yimu Shengjin Decoction In The Treatment Of Primary Dysmenorrhea

ObjectiveTo observe the clinical efficacy of Jiawei Yimu Shengjin Decoction in treating primary dysmenorrhea of Qi stagnation and blood stasis type,summarize the law of clinical medication,and confirm the effectiveness,scientificity and safety of Jiawei Yimu Shengjin Decoction in treating diseases of this syndrome type.MethodFrom January 2017 to August 2018,76 female patients who met the diagnostic criteria of primary dysmenorrhea in Shenzhen Hospital of Traditional Chinese Medicine were selected.They were divided into experimental group and control group with 38 cases in each group according to random number table method.During the experiment,7 cases of interruption or case history loss occurred in experimental group and 6 cases of interruption or case history loss occurred in control group,which were rejected.In addition,31 cases in the experimental group and 32 cases in the control group participated in the statistical results.The experimental group was treated with Jiawei Yimu Shengjin Decoction,while the control group was treated with ibuprofen sustained-release capsule.The two groups were treated for three consecutive courses,namely,three menstrual cycles.The scores of dysmenorrhea symptoms,TCM syndromes,dysmenorrhea intensity,prostaglandin E2(PGE2),prostaglandin F2 a(PGF2 a),β-endorphin(β-EP),thromboxane degradants(TXB2),prostacyclin degradants(6-Keto-PGF1 a),tumor necrosis factor a(TNF-α)and interleukin 6 were compared before and after treatment.Changes of interleukin-6(IL-6)and interleukin-10(IL-10)were studied,and the safety was tested.Results(1)Comparing the curative effect indexes,there was no significant difference in dysmenorrhea symptoms,TCM syndromes and dysmenorrhea intensity scores between the two groups before intervention(P>0.05);after intervention,the dysmenorrhea symptoms,TCM syndromes and dysmenorrhea intensity scores of the two groups were lower than those before treatment(P<0.01),and the scores of the experimental group were significantly lower than those of the control group(P<0.01),the difference of three scores in the experimental group was significantly different from that in the control group(P<0.05),suggesting that the experimental group was better than the control group in improving dysmenorrhea symptoms,TCM syndromes and intensity of dysmenorrhea.(2)The results of laboratory observation showed that there was no significant difference in PGE2,PGF2α,β-EP,TXB2,6-Keto-PGFl a,TNF-a,IL-6 and IL-10 between the two groups before intervention(P>0.05);after intervention,the levels of PGE2,PGF2α,β-EP,TXB2,6-Keto-PGFl a,TNF-α,IL-6 and IL-10 in the two groups were significantly improved compared with those before treatment(P<0.05).The endocrine indexes in the experimental group were significantly lower than those in the control group(P<0.05),suggesting that the experimental group was significantly better than the control group in maintaining the body’s endocrine balance.ConclusionModified Yimu Shengjin Decoction has good effect in treating primary dysmenorrhea of Qi stagnation and blood stasis type.It can effectively improve dysmenorrhea symptoms,TCM syndromes and intensity of dysmenorrhea,maintain endocrine balance of the body,thus significantly alleviate dysmenorrhea.Dysmenorrhea symptoms and intensity are related to the levels of PGF2 a,PGE2,β-EP,TXB2 and 6-Keto-PGF1α.Its clinical application has been proved safe and effective.Pedestrian animal experiments and larger sample clinical studies clarify its mechanism of action.