The Observation Of The Therapeutic Effect Of Changyu Enema Recipe On Ulcerative Colitis(Rectal Type) Of Large Intestine Damp-heat Syndrome And Its Clinical Study Of Serum IL-17 And IL-23

Objective:Patients with ulcerative colitis(rectal type)of the large intestine Damp-Heat syndrome were treated with Changyu Enema Recipe to observe the changes of clinical manifestations before and after treatment,and to detect the levels of IL-17 and IL-23 in the serum of patients.To explore the clinical efficacy and mechanism of the treatment of UC and the related effects of IL-23/IL-17 axis in the pathogenesis and changes of UC,in order to give play to the advantages of traditional Chinese medicine for the treatment of UC.Methods:From January 2018 to December 2018,60 patients who met the requirements of this study were selected from the patients who were admitted to the First Affiliated Hospital of Anhui University of Chinese Medicine,and were divided into treatment group and control group by random number table method,with 30 patients in each group.The patients in the treatment group were treated with Changyu Enema Recipe retention enema every night,and the patients in the control group were treated with Mesalazine suppository every night.the total scores of TCM syndrome,Southerland disease activity index(DAI)scores,mucosal mirror scores,and serum IL-17 and IL-23 in the two groups were observed before and 9 weeks after treatment,respectively.The effect of TCM syndrome and clinical comprehensive effect were evaluated after two treatment approaches.Results:After 9 weeks of treatment,the total scores of TCM syndrome,Southerland disease activity index(DAI)scores,mucosal mirror scores,and serum IL-17 and IL-23 levels were significantly lower than those before treatment(P<0.05).There was a statistically significant difference(P<0.05)between the two groups in the total scores of TCM syndrome,Southerland disease activity index(DAI)scores,and the levels of IL-17 and IL-23;There was no significant difference in the comparison of mucosal mirror scores(P>0.05).The effect of TCM syndrome and clinical comprehensive effect of the treatment group were better than the control group(P<0.05).During the treatment period,one patient in the control group developed flatulence.One patient had nausea and discomfort,and the treatment group had no corresponding discomfort.Conclusion:This study showed that Changyu Enema Recipe is effective in treating mild and moderate UC(rectal type)of the large intestine Damp-Heat syndrome with less side effects.This prescription may effectively improve the specific clinical manifestations of patients by regulating the IL-23 /IL-17 axis,and the incidence of UC may be related to the imbalance of this axis.