Analysis Of Risk Factdrs In Patients With Cognitive Impairment In Acute Stage Of Ischemic Stroke

BackgroundIschemic stroke is a syndrome caused by acute cerebral circulation disorder,which is one of the common diseases in neurology.So far,ischemic stroke has become the first disabling and fatal disease in our country,which brings heavy burden to the society.With the development of science and technology and medical technology,the mortality rate of stroke is decreasing gradually.However,the problem of post-stroke neurological impairment has been paid more and more attention by researchers,and about 30% of people have post-stroke neurological impairment every year.Stroke may lead to cognitive impairment.There have been some analysis of the risk factors of ischemic stroke in the past,and acupuncture The analysis of risk factors such as serological changes in patients with cognitive impairment in acute stage of ischemic stroke needs to be further supplemented,if early identification of patients with post-stroke cognitive impairment may occur in all aspects of risk factor analysis of the patient,It may be useful to judge the prognosis of cognitive function and to delay the progression of cognitive impairment in patients with stroke by corresponding intensive treatment in the early stage.This paper analyzed the patients with cognitive impairment in acute stage of ischemic stroke in the first affiliated Hospital of Henan University and divided them into normal cognitive function group after stroke,non-dementia group after stroke and cognitive impairment group after stroke according to the severity of cognitive impairment.Discussion on the acute phase of ischemic apoplexy.The changes of general,serological and stroke characteristics in patients with cognitive impairment are helpful to deepen the clinician’s exploration on the prognosis of cognitive impairment after stroke.ObjectiveTo explore the general situation,serology and different changes of stroke characteristics in patients with cognitive impairment in acute stage of is chemic stroke.MethodFrom April 2017 to October 2018,patients with ischemic stroke were hospitalized in the Department of Geriatric Neurology,the first affiliated Hospital of Henan University.All patients were tested with neurologic cognitive function scale when the condition was stable within 14 days after admission.According to the expert consensus of post-stroke cognitive impairment management,eligible patients were divided into three groups: 1NCI group with normal cognitive function after stroke(no cognitive impairment,NCI),2PSCIND group: post-stroke cognitive impairment non-dementia group(post-stroke Cognitive impairment no dementia,PSCIND),3PSD group: post stroke dementia group(post-stroke dementia,PSD).The patients in each group were assessed with mini-mental state examination scale,Montreal Cognitive behavior scale,National Health Center Stroke scale and so on.The patients’ basic information such as gender,age,education level,height,weight and so on were collected.Collect risk f actors of vascular disease,such as hypertension,diabetes mellitus,stroke history,etc.;perform head MRI statistical report within 3 days;collect patient’s serum Such as uric acid,total cholesterol,triglyceride,high density lipoprotein,low density lipoprotein,serum creatinine,blood urea nitrogen,hypersensitivity C-reactive protein,homocysteine,etc.All the above data were statistically analyzed with SPSS20.0 software.ResultsThe study included 200 patients,120 cases in the NCI group,44 cases in the PSCIND group and 36 cases of patients in the PSD group.The incidence of cognitive impairment was 40% in patients with acute ischemic stroke,of which the incidence of non-dementia was 22%,and the incidence of cognitive impairment reached dementia was 18%.There were significant differences in age,sex,education level,body mass index(physical Mass Index,BMI),stroke history,history of hypertension and history of diabetes mellitus in 3 groups of NCI Group,PSCIND Group and PSD Group(P<0.05);there were significant differences in total cholesterol,low density lipoprotein-cholesterol,serum creatinine,urea nitrogen,hypersensitive C-reactive protein and homocysteine levels(P<0.05);there were significant differences in cerebral infarction,cerebral atrophy and lacunar infarction,and severity of stroke(P<0.05).Sex,age,BMI,multiple lacunar infarction,serum total cholesterol,stroke history are the risk factors for the occurrence of PSCIND,education level is the protective factor of PSCIND occurrence;sex,age,multiple lacunar infarction,serum total cholesterol,stroke history is the risk factor of PSD occurrence;sex,age,BMI,multiple lacunar infarction,serum total cholesterol and stroke history are the risk factors for cognitive impairment in patients with acute ischemic stroke,and educational level is the protective factor for cognitive impairment in patients with ischemic stroke in acute stage.ConclusionSex,age,multiple lacunar infarction of BMI,total cholesterol and stroke history were the risk factors of cognitive impairment in patients with acute ischemic stroke,and the level of education was the protective factor of cognitive impairment in patients with acute ischemic stroke.