| Objectives:Comparison of the clearance of small molecule and medium macromolecular urea in patients with peritoneal dialysis(PD)by continuous ambulatory peritoneal dialysis(CAPD)and automated peritoneal dialysis(APD).This makes the two kinds of peritoneal dialysis methods have a better understanding of the removal of uremic toxins,which can help the clinical work to a certain extent,and seek a peritoneal dialysis method that is more in line with the actual needs of patients.Methods:Retrospectively selected from January 2015 to April 2018,the Department of Nephrology,Zhujiang Hospital,Southern Medical University,underwent peritoneal dialysis catheterization.52 cases of APD were routinely performed for peritoneal dialysis.The study group used 1:2 matching to collect the same period.104 cases of CAPD cases served as a control group.General patient data,uremic toxin indicators before and after dialysis,and other laboratory indicators were collected.Result:1.Correlation analysis results:1 There is a significant positive correlation between blood phosphorus and urea nitrogen(P<UNK>0.05);There was a significant negative correlation between blood calcium,serum triglycerides,total carbon dioxide and urea nitrogen(P<UNK>0.05);2 Blood creatinine and serum albumin,blood phosphorus index showed positive correlation(P<UNK>0.05)while hemoglobin,total carbon dioxide index and blood creatinine showed significant negative correlation(P<UNK>0.05).3 The relationship between parathyroid hormone and serum albumin was positive(P<UNK>0.05).2.Comparison of two groups of small molecular solute removals:BLUN indicator results:1.Available from repeated measurement variance results,intergroup comparison:The differences between groups are statistically significant(F = 7.485,P = 0.007);2.Time trend:The time change trend is statistically significant(F = 78.2145 P<UNK>0.001),and the group interaction with time is not statistically significant(F = 0.208,P = 0.695),That is,there was no significant difference in the change of BUN index at 3 time points between the two groups of patients.Scr-indicator results:1.Available from repeated measurement of variance,intergroup comparison:the difference between groups is statistically significant(F = 20.0205,P<UNK>0.001);2.Time trend:Time change trends are statistically significant(F = 15.276,P<UNK>0.001),and group and time interactions are statistically significant(F = 5.185,P = 0.011),That is,there was a statistical difference between the two groups of patients with Scrs at 3 points in time.3.Comparison of macromolecular solute clearance in two groups:A parathyroid hormone indicator result:1.Available from repeated measurement variance,intergroup comparison:There is no statistical difference between groups(F = 0.002,P=0.964)(see table 9);2.Time trend:The time change trend is statistically significant(F = 6.106,P = 0.003).and the group interaction with time is not statistically significant(F = 1.851,P = 0.161),That is,there was no significant difference between the two groups of patients with parathyroid hormone index measured at 3 points in time(see Figure 3).VitB12 indicator results:1.Available from repeated measurement variance results,intergroup comparison:There is no statistical difference between groups(F = 1.107,P = 0.294)(see table 9);2.Time trend:The time change trend is statistically significant(F = 2.211,P = 0.112),and the group interaction with time is not statistically significant(F = 0.558,P = 0.570),That is,there was no significant difference:in the change of VitBl2 in three time points.Conclusion:1.CAPD patients have better clearance for small molecular substances than APD patients;2.CAPD patients and There was no difference in the clearance of medium and macromolecular solutes in APD patients. |
PDF Full Text Request