Clinical Research On IBS-D Of Spleen Deficient And Damp-heat Syndrome By Sijun Pingwei Baijiang Decoction

Objective:The purpose of this study is to observe the safety and effectiveness of Sijun Pingwei Baijiang Decoction in the treatment of IBS-D(spleen deficiency and damp-heat type)based on syndrome differentiation,and to provide a new treatment idea for IBS-D with traditional Chinese medicine.Methods:According to the research program,80 cases of IBS-D(spleen deficiency and damp-heat syndrome)diagnosed in the outpatient department of spleen and stomach disease of Yunnan Province Hospital of TCM from January 2018 to January 2019 were selected as the research objects.They were randomly divided into experimental group and control group with 40 cases in each group.The treatment group was treated with Sijun Pingwei Baijiang Decoction;the control group was treated with Shenling Jianpiwei Granule;the treatment lasted for 4 weeks.The scores of single and total TCM syndromes of the two groups were evaluated before and after Results:1.Total integral of TCM syndromes:The total scores of TCM syndromes of the two groups before and after treatment were significantly different(P < 0.001).After treatment,the total scores of TCM syndromes in the treatment group were significantly different from those in the control group(P < 0.001).2.Single integral of TCM syndromes: In the treatment group,there were significant differences in the scores of TCM syndromes before and after treatment(P < 0.001).Contrast before and after treatment of single integral of TCM syndromes in the control group: abdominal dull pain and/or abdominal distension and discomfort,feces increased,diet decreased before and after the contrast difference was extremely significant(P < 0.001);dry mouth,limb fatigue and fatigue before and after the contrast was significant statistical significance(P < 0.05);feces sticky and uncomfortable,anal burning before and after the contrast was no difference.Significant statistical difference(P > 0.05).In the treatment group,there were significant differences in the scores of abdominal pain,abdominal distension and discomfort,fecal stickiness,dry mouth and anus burning in the control group(P < 0.001);there were no significant differences in the scores of feces,diet and limb fatigue after treatment(P > 0.05).3.There were no obvious adverse reactions in both groups.Research conclusions:Sijun Pingwei Baijiang Decoction can improve the overall symptoms of IBS-D patients with spleen deficiency and damp-heat syndrome.It has no obvious adverse reactions and good safety.This study can provide a new thinking and clinical basis for TCM treatment of diarrhea-predominant irritable bowel syndrome.