Clinical Observation Of Xinkai Kujiang Therapy For Chronic Non-atrophic Gastritis With Spleen-stomach Damp-heat Syndrome

Objective To explore the efficiency and rationality of Xinkai Kujiang Therapy in the treatment of chronic non-atrophic gastritis(CNAG)with Spleen-stomach damp-heat syndrome by Pingpi Decoction administration,so as to provide traditional Chinese medicine-based strategies in the treatment of CNAG with Spleen-stomach damp-heat syndrome.Methods a total of 80 patients of CNAG were enrolled in the clinical trial from Dec 2016 to Aug 2018.Diagnosis was performed according to standard criteria which included clinical,gastroscopy,pathology,and TCM differentiation.The patients were randomly divided into the treatment group and the control group.There was no significant differences in age,sex,course of disease and condition between the two groups(P > 0.05).In the treatment group,200 ml Pingpi Decoction was provided both in the morning and evening,and was given 30 minutes after meals;While the control group was orally administered with one bag Sanjiuweitai Granules twice a day.Both groups took 4 weeks as a course of treatment.During the treatment,patients were advised to eat light diet,to relax their mood,to maintain regular rest time,and to refrain spicy food,tobacco,alcohol,and other drugs which may affect the results.After one course of treatment,the curative effect was determined by evaluating the main symptoms,TCM signs,gastroscopy and pathological effects of the two groups.Results1.Total efficiency:both Pingpi Decoction and Sanjiuweitai Granule could improve the discomfort symptoms of CNAG patients with spleen-stomach damp-heat syndrome.However,Pingpi Decoction significantly showed dramatically higher total effectively rate compared with the control group.2.TCM syndrome:both Pingpi Decoction and Sanjiuweitai Granule alleviated abdominal distension and pain,bitter mouth,sticky stool,nausea,general nausea,weight drowsiness.What’s more,Pingpi Decoction group showed a better improvement than the control group.3.Endoscopy curative effect:Pingpi Decoction and Sanjiu weitai Granule can attenuate the mucosa damage of patients,while the Pingpi Decoction treated patients showed a better remission in mucosa inflammation and damage.Conclusions Pingpi Decoction is more effective in improving the CNAG TCM syndrome including abdominal pain,bitter mouth,sticky stool,nausea,general nausea and weight drowsiness than Sanjiu weitai Granule.On the other hand,it’s superior to Sanjiu weitai Granule in alleviating mucosa damage and shows no side effects.Taken together,Pingpi Decoction is an effective and safe strategy to treat CNAG patients with spleen-stomach damp-heat syndrome.