Study On The Intervention Of Non-dementia Vascular Cognitive Dysfunction After Acute Cerebral Infarction

Objective: To investigate the incidence of non-dementia vascular cognitive impairment after acute cerebral infarction and the effect of donepezil hydrochloride on cognitive function in patients with non-dementia vascular cognitive impairment after acute cerebral infarction,and to provide evidence for the prevention and treatment of non-dementia vascular cognitive impairment in clinical practice.Methods: The Montreal cognitive function rating scale was used to screen151 patients with acute cerebral infarction,and the incidence of non-dementia vascular cognitive dysfunction was calculated.At the same time,the general data of age,gender,years of education and so on were collected.Patients with non-dementia vascular cognitive impairment were randomly divided into intervention group and control group according to the order of enrollment.On the basis of secondary prevention of cerebral infarction,patients in the intervention group were given 5 mg of donepezil hydrochloride orally every night,while patients in the control group were given secondary prevention of cerebral infarction.Three months after the onset of cerebral infarction,thescores of Montreal cognitive function scale were evaluated again to compare the differences between the two groups before and after treatment.Result: Among 151 patients with acute cerebral infarction that met the inclusion criteria,47 patients with non-dementia vascular cognitive dysfunction were found,and the incidence of non-dementia vascular cognitive dysfunction after acute cerebral infarction was 31.1%.The total score of Montreal cognitive function rating scale and visual spatial executive function,attention,language ability,abstraction,delayed recall and orientation were lower in patients with non-dementia vascular cognitive impairment than in patients with normal cognitive function,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the total score of Montreal scale and its sub-items between the intervention group and the control group(P > 0.05).After treatment,the total score of Montreal scale and the scores of visuospatial executive ability,attention,verbal fluency and delayed memory in the experimental group were significantly improved,with statistically significant differences(P<0.05).In the control group,there was no significant difference in the Montreal scale total score and its sub-score after 3 months compared with that before treatment(P > 0.05).After treatment,the total score of the Montreal scale,visual-spatial executive ability and delayed memory of the experimental group were higher than that of the control group,and the difference was statistically significant(P < 0.05).Conclusions: The incidence of non-dementia vascular cognitive dysfunction after acute cerebral infarction was 31.1%.After acute cerebral infarction,the visuospatial executive function,attention,language ability,abstraction,delayed recall and orientation cognition of patients with non-dementia vascular cognitive dysfunction were significantly impaired.Donepezil hydrochloride can improvethe overall cognitive function level of patients with non-dementia vascular cognitive dysfunction after acute cerebral infarction,and it has significant improvement effect on visual spatial executive ability and delayed memory of patients with non-dementia vascular cognitive dysfunction.Donepezil hydrochloride plays an important role in the prevention and treatment of non-dementia vascular cognitive dysfunction after acute cerebral infarction.