Cerebral Infarction Cognitive Impairment In Clinical Research

Objective Cerebral infarction is one of common diseases which threatens severely healthy of human especial middle-old people, patients often are left behind different degree cognitive function impairment, which not only affect quality of life and social adaptation ability of patients, but also bring patient, family and society great psychic pain and heavy economic burden. In this study, cognitive function impairment and its characteristics and related risk factor were investigated to provide experimental basis for its early diagnosis, prevention and cure.Methods The cognitive functions in 22 patients with cerebral infarction dementia, 44 patients with cerebral infarction no dementia and 30 normal subjects were evaluated with mini-mental state examination (MMSE) and Wechsler adult intelligence scale-revised (WAIS-R), event related potential P300 was recorded, cerebral infarction position and quantity of infarction focus were detected by magnetic resonance imaging , blood pressure and serum index such as blood glucose, blood fat were detected and related clinic data was analyzed in all subjects.Results1. Compared with cerebral infarction no dementia group and normal control group, there was a significant decrease in MMSE and its time orientation, place orientation, language immediate memory, attention and calculation, short-range memory, Language comprehension, figure delineation, WAIS and intelligence quotient (IQ), verbal scale (VS) and verbal intelligence quotient (VIQ), performance scale (PS) and performance intelligence quotient (PIQ) in the cerebral infarction dementia group, compared with normal control group, there also was a significant decrease in MMSE and its Language comprehension, figure delineation, PS and PIQ in the cerebral infarction no dementia group.2. The P300 latency in the cerebral infarction dementia group was significantly longer than those in the cerebral infarction no dementia group and normal control group, the P300 latency in the multi-focal cerebral infarction no dementia group was obviously longer than those in the mono-focal cerebral infarction no dementia group.3. Patient ratio of multi-focal cerebral infarction in the cerebral infarction dementia group was obviously higher than those in the cerebral infarction no dementia group, the cognitive functions in the mono-focal and multi-focal cerebral infarction dementia were significantly lower than those in the mono-focal and multi-focal cerebral infarction no dementia, the cognitive functions in the multi-focal cerebral infarction no dementia were obviously lower than those in the mono-focal cerebral infarction no dementia.4. The age in the cerebral infarction dementia was obviously higher than those in the cerebral infarction no dementia group and normal control group, compared with the nomal control group, there was a significant increase in patient ratio of diabetes and hyperlipemia, contractive pressure and diastolic blood pressure, fasting blood glucose, triglyeride, low density lipoprotein and D- dimmer in the cerebral infarction dementia group and no dementia group.Conclusion1.There is an extent degree early cognitive function impairment, which displays damage of performance ability, reading and apprehension, figure delineation, general cognitive function impairment including memory, orientation, language cognition, vision space, apprehension, performance ability appear in patient with dementia.2.There is an important value in P300 detection for evaluation of cognitive function impairment in the patient with cerebral infarction dementia and multi-focal cerebral infarction no dementia, evaluation of cognitive function impairment depend on neuromental scale combined with imageological examination.3. Mmulti-focal cerebral infarction, age, hypertension, hyperlipemia and diabetes might be the risk factors for cognitive function impairment of cerebral infarction.