| ObjectiveThe aim of our study was to investigate the adherence of medicine treatment in patients with coronary heart disease after coronary stenting implantation for 1 year,including dual anti-platelet drug adherence and lipid-lowering drug adherence,and to explore related factors to improve medicine adherence of secondary prevention of coronary heart disease.MethodA total of 537 patients diagnosesd with coronary artery disease for the first time and undergoing coronary coronary stenting from January 2017 to December 2017 were enrolled.The discharge orders including dual anti-platelet drugs(aspirin and clopidogrel/Ticagrelor)and a lipid-lowering drug,was given before discharge as well as health education.Patients with malignant tumors,severe liver dysfunction,kidney dysfunction,coagulopathy,hematological diseases,and cognitive dysfunction have been excluded.The clinical data were collected and the patients were followed up by telephone.The follow-up included the patient’s dual anti-platelet drugs adherence,lipid-lowering drug adherence,and the number of visits on hospital for review,as well as whether to perform coronary angiography or not within one year after PCI.According to the dual anti-platelet drugs adherence,the patients were divided into two groups: the group with good dual anti-platelet drugs adherence and the group with poor dual anti-platelet drugs adherence;the patients were divided into another two groups according to the lipid-lowering drug adherence,that is,the group with good lipid-lowering drug adherence and the group with poor lipid-lowering drug adherence.Then we explore the influencing factors of the treatment adherence of the two kinds of drugs.Using SPSS20.0 statistical software,the measurement data were expressed as mean ± standard deviation;the count data was expressed as frequency and percentage,and the chi-square test was used for comparison;Logistic regression analysis was performed with medicine adherence as the dependent variable(Y)and other variables as the independent variable(X)to analyze the impact of various factors on medicine adherence.P < 0.05 was statistically significant.Results1.Patients taking anti-platelet drugs one year after PCI: 441 patients in the good adherence group(82.1%,441/537),96 patients(17.9%,96/537)in the poor adherence group.2.One year after PCI,lipid-lowering drugs were taken in 458 patients(85.3%,458/537)with good adherence,and 79 patients(14.7%,79/537)without poor adherence.3.Factors significantly associated with dual anti-platelet drugs adherence included age,age grouping,marital status,education level,occupational status,monthly income,type of medical insurance,place of residence,presence or absence of cardiovascular symptoms,number of other drug types,number of reviews;and age,marital status,monthly income,presence or absence of cardiovascular symptoms,number of reviews,and number of other drug types were the main influence factors.(P <0.05)4.Factors related to lipid-lowering drug adherence included marital status,education level,occupational status,monthly income,and type of medical insurance,place of residence,number of stents,number of other drug types,number of reviews,whether to perform coronary angiography or not;and marital status,monthly income,number of stents and number of other drug types were the main influence factors.(P < 0.05)Conclusion1.Compared with the lipid-lowering drug adherence,the dual anti-platelet drugs adherence is slightly poorer,and the random withdrawal is the primary cause of poor medication adherence.2.Marital status and number of other drug types were the main influence factors of both dual anti-platelet drug adherence and lipid-lowering drug adherence;age grouping and number of review are also the main influence factors of dual anti-platelet drug adherence;monthly income and number of stents the main influence factors of lipid-lowering drug adherence too. |
PDF Full Text Request