Study On Syndrome Related Factors And Analysis Of Prescription Regularity In 311 Cases Of Rheumatoid Arthritis In Yunnan Province

Objective:Through the collection of clinical data,Analyze the distribution pattern of RA TCM syndromes,and the relationship between syndromes and age,duration of disease,gender,disease activity,and laboratory indicators.Data mining was conducted based on the TCM inheritance assistance platform software(V2.5)to analyze the law of medication.Methods:The clinical information of 311 patients with RA in the Department of Rheumatology of Yunnan Provincial Hospital of Traditional Chinese Medicine was collected.Collect and record the basic information,four diagnoses,syndromes,laboratory indicators and traditional Chinese medicine prescriptions of RA patients,and design a questionnaire.Relevant data was entered with EpiData3.1,and finally all data was exported and analyzed with SPSS22.0 and Excel 2010 software;The TCM inheritance auxiliary platform software(V2.5)focuses on the inclusion of symptoms and prescriptions for statistical analysis to explore the rule of treatment of RA by Professor Tang Xiaohu.Results:1.Among the 311 cases,female patients(74.92%)were three times more than male patients(25.08%);Grouped by age,the proportion of the group aged 45-60 and over 60 was 38.3%;the age of 18-45 was 23.6%;In terms of syndromes,wind-colddampness syndrome(42.7%)is the most common type,followed by cold-heat syndrome(24%),rheumatic fever syndrome(10.3%),deficiency of qi and blood(8.7%),deficiency of liver and kidney(8.4%),phlegm and blood stasis syndrome(4.2%),and kidney deficiency and cold coagulation syndrome(1.6%).There was no statistically significant difference between syndrome and gender,age,and duration of disease(P>0.05).2.The number of joint tenderness,joint swelling,DAS28 score,disease activity,erythrocyte sedimentation rate,C-reactive protein,and RF-IgM were statistically significant among the syndrome types(P <0.05).There were no significant differences in RF-IgG,RF-IgA,and anti-CCP antibodies between RA patients with different syndromes(P>0.05).DAS28 score,ESR value and CRP value of rheumatic fever bi syndrome were the highest,and the number of joint tenderness and swelling was the highest.Deficiency of qi and blood is vice versa.3.The following results were obtained by using the TCM inheritance assistance platform software(V2.5): The drugs frequently used by tutors in treating RA were successively liquorice,cassia twig,rhizoma atractylodis,rhizoma rhizoma ligustici;The frequency of “four properties” is the highest in warm Chinese medicine,followed by flat,cold,cool and hot drugs.Through the analysis of "five tastes",the most frequently used drugs were ganxin and bitter;Through the analysis of "rule of composition",it was found that cassia twig,longhuao and licorice were closely related to each other.Eight new prescriptions were obtained based on entropy clustering.The network relationship of drug-syndrome-symptom was obtained by "prescription-syndrome analysis".Conclusion:1.Among 311 RA patients in yunnan,wind-cold-dampness syndrome was the most common type.2.The ratio of male to female patients with RA is about 1:3.Female patients over 45 years old had the most cases.The longest course is phlegm and blood stasis syndrome,rheumatic fever bi syndrome is the shortest course.3.The highest disease activity was rheumatic fever bi syndrome and the lowest was deficiency of qi and blood.4.Professor Tang Xiaohu is good at grasping the main symptoms when treating and treating RA.The prescriptions are flexible and changeable,pay attention to the compatibility of odors,and make good use of the compatibility of the prescriptions.It is worth learning.