Retrospective Analysis Of Prognostic Factors In Elderly Patients With Stage Ⅰ-ⅢA Non-smal-cell Lung Cancer After Radical Resection

Purpose To identify prognostic factors associated with survival in elderly patients with non-small cell lung cancer(NSCLC)after radical resection.Patients and methods Totally 82 elderly patients(≥60 years old)who underwent radical resection for pathologic stage I-IIIA at the Cancer Institute&Hospital of the Chinese Academy of Medical Sciences between August 2003 and July 2011 were enrolled in this study.And the correlation between clinical characteristics and prognostic factors of DFS was evaluated by Cox proportional hazards regression analysis.Results The median of DFS was 38.28 months(95%[confidence interval,CI]15.583-60.967 months).1,2,5-year DFS rates were 73.2%,57.3%and 35.4%,respectively.In univariate analysis,patients with squamous cell carcinoma and less lymph node involvement have superior survival.Patients with adjuvant chemotherapy(ACT)and 4 therapy cycles appeared to increase survival for elderly patients with resected NSCLC(P<0.05).In multivariate analysis,patients with squamous cell carcinoma,less lymph node involvement and receiving ACT had superior survival(P<0.05).Conclusions Pathological type,lymph node involvement and ACT status were identified as the independent factors influenced the prognosis(P<0.05)by Cox analysis.ACT appeares to increase survival for elderly patients with resected NSCLC.