Correlation Between T/E2 Ratio And Male Patients With Coronary Heart Disease

Objective:To analyze the relationship between serum testosterone(T),estradiol(E2)and testosterone/estradiol ratio(T/E2)in male patients with coronary heart disease and risk factors of coronary heart disease,and to provides a new reference index for clinical prediction of male coronary heart disease.Method:A total of 97 male patients diagnosed with coronary heart disease by coronary angiography(CAG)in our hospital from October 2018 to January 2019 were selected as the CHD group,and divided into two groups:Han dynasty and the Korean nationality.A total of 90 cases of males with no abnormal coronary arteries confirmed by the department of physical examination of our hospital at the same period were randomly selected as the control group,and divided into two groups:Han dynasty and the Korean nationality.Coronary angiography results were recorded in all patients,and CHD related blood indexes(CHO,TG,HDL-C,LDL-C,BUN,CREA,UA,CysC,FBG,Hs-CRP)were detected.The concentration of T and E2 in serum was determined by magnetic particle chemiluminescen-ce.The Gensini coronary score was used to assess the severity of coronary artery stenosis.According to the number of coronary heart disease lesions divided into:mild group(lesions 1 branch);Moderate group(2-3 lesions);Severe group(lesion>3).Non-parametric test,univariate ANONA analysis and Logistic regression analysis were used to analyze CHD risk factors.Results:(1)Comparison of serum indexes between CHD group and control group,CHO,TG,LDL-C,CysC and Hs-CRP levels in the CHD group were significantly higher than those in the control group(all P<0.05).BMI and HDL-C levels were significantly lower than those in the control group(all P<0.05),there were no significant differences in age,ethnicity,diabetes,hypertension,BUN,CREA,UA and FBG levels between the two groups(all P>0.05).(2)Compared with the control group,serum T and T/E2 levels of CHD patients were significantly decreased(3.98 ± 1.97 ng/ml vs.4.68 ± 2.61 ng/ml,P=0.029;89.65 ± 47.92 vs.168.95±70.88,P<0.001);Serum E2 level was significantly increased in CHD patients(50.74 ± 24.62 pg/m vs.27.66±6.06 pg/m,P<0.001).(3)The contents of T,E2 and T/E2 in CHD group and control group were correlated with age(≤65years old;>65years old),hypertension and diabetes were not significantly different(P>0.05).(4)Parameters of T,E2,T/E2 content and severity of coronary heart disease were shown:there was no significant difference between the content(≤10;10-22;22-45;>45)of T,E2 and T/E2 in the Gennisi score quartile array(P>0.05).(5)Logistic regression model analysis showed that T,E2 and T/E2 indexes were statistically significant both before and after adjustment(BMI,CHO,TG,LDL-C,HDL-C),and they are independent risk factors for coronary heart disease,T(OR=0.826,95%CI[0.690-0.989],P^=0.038)、E2(OR=1.231,95%CI[1.142-1.327],P^<0.001)、T/E2(OR=0.972,95%CI[0.962-0.982],P^<0.001).(6)ROC curve results are shown:①The area under the T curve(0.614,95%CI[0.540-0.684],P=0.006),the cut off value was 5.147 ng/ml,the sensitivity was 84.54%,and the specificity was 36.67%.②The area under E2 curve(0.894,95%CI[0.841-0.934],P<0.001),cut off value was 34.194 pg/ml,sensitivity was 81.44%,specificity was 91.11%.③The area under the T/E2 curve(0.844,95%CI[0.784-0.893],P<0.001),the cut off value was 11.914,the sensitivity was 80.41%,and the specificity was 75.56%.Conclusion:(1)Serum T,T/E2 levels in CHD patients decreased significantly;E2 levels were significantly higher,It suggests that T,E2 and T/E2 may be related to the occurrence and development of coronary heart disease(2)T,E2 and T/E2 are independent risk factors for CHD.(3)The detection of T,E2 and T/E2 have important reference value for the clinical diagnosis of coronary heart disease.