The Expression Of ARHGAP10 In Non-small Cell Lung Cancer And Clinicopathological Significance

Objective: To study the expression of ARHGAP10 in Non-small cell lung cancer(NSCLC)and analyze its clinicopathological features,and provide a potential new approach for diagnosis,treatment and prognosis of Non-small cell lung cancer.Method: Selecting 50 cases with complete clinical data of NSCLC patients who underwent surgical resection and 30 cases of normal lung tissue adjacent to carcinoma patients in our hospital from January 2011 to December 2013,using immunohistochemistry to detect ARHGAP10 expression,the clinical pathological characteristics and prognosis were analyzed.Result: The positive expression rate of ARHGAP10 in Non-small cell lung cancer tissues was statistically lower than that in adjacent non-cancerous lung tissues(P<0.05).The expression of ARHGAP10 correlated with degree of tumor differentiation,lymph node metastasis,TNM stage(P<0.05),but no correlated with age,sex,histological types,tumor size,(P>0.05).1-year,3-year,5-year cumulative survival rates were also statistically different between ARHGAP10 positive expression and negative expression in Non-small cell lung cancer patients(P<0.05).Conclusion: The expression of ARHGAP10 in Non-small cell lung cancer was more statistically down-regulated than that in adjacent normal lung tissue,and it was closely related to some of the major malignant biological characteristics of the tumor,and it was negatively correlated with survival time,suggesting that ARHGAP10 expression in Non-small cell lung cancer may have some impacts on the occurrence,development of Non-small cell lung cancer and play an important role in its prognosis.Therefore,to promote the expression of ARHGAP10 in lung cancer tissues and thus effectively control the tumor,it is expected to become a new approach for the prevention and treatment of Non-small cell lung cancer.