Clinical Observation Of Accurate Hyperthermic Intraperitoneal Chemotherapy For Advanced Peritoneal Carcinoma

Objective:To observe the clinical efficacy of precise hyperthermic intraperitoneal chemotherapy(hyperthermic intraperitoneal chemotherapy HIPEC)in the treatment of advanced peritoneal carcinoma(peritoneal cancer PC);that is,to observe the survival period,quality of life,such as Karnofsky(KPS),degree of bloating,improvement of ascites,and tumor marker CEA.The changes and safety of Ca19-9,Ca125 provide more data for accurate clinical methods of hyperthermic intraperitoneal chemotherapy for advanced peritoneal carcinoma.Methods:110 patients with peritoneal carcinoma of abdominal and pelvic origin who were admitted to the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine were selected from January 2015 to January 2017.All patients were accompanied by ascites of different degrees and all had pathology.Or cytological confirmation of malignant ascites.We made a count on the survival after HIPEC treatment and observed the changes in patients with vital signs during treatment and adverse reactions and related complications.At the same time,we evaluated the ascites improvement,KPS score,abdominal~1distension,tumor markers CEA,Ca19-9.Changes of Ca125.After that,we used SPSS20.0 statistical software to anylase the Statistical data,and made an evaluation of clinical efficacy and safety of accurate hyperthermic intraperitoneal chemotherapy for advanced peritoneal carcinoma.Results:There was no significant difference in gender and age among 110 patients with advanced peritoneal carcinoma(P>0.05).The median survival time was 11 months after HIPEC treatment.The total effective rate of malignant ascites was 90.1%.KPS score,degree of bloating,the tumor markers CEA,Ca19-9,and Ca125 had statistical significance before and after 2 weeks of treatment(P<0.05).The vital signs before and during the HIPEC treatment were Slightly higher and were within the normal range.All the patients treated with HIPEC did not show bone marrow suppression in their side effects.There were only nausea,vomiting,abdominal distention,abdominal distension,and other discomforts.Grade I toxicities were 13(11.8%),and grade II toxicities were 5(4.6%).There were no grade III-IV toxicities;the first complications that occurred included hypoproteinemia,electrolyte imbalance,intestinal obstruction,and planting of potentional holes.The incidence rates were 13.6%,9.1%,4.5%,and0.9%,respectively.All adverse reactions and most of the complications were relieved after symptomatic treatment.Conclusion:1.HIPEC treatment of advanced peritoneal cancer has a good effect.It can appropriately extend the survival of patients;2.The recent clinical effect of HIPEC was satisfactory.It can significantly reduce the amount of malignant ascites and relieve abdominal distension and I ncrease the KPS score and improve the patients’quality of life of;3.After the treatment with HIPEC,the tumor markers CEA,Ca19-9,Ca125 will decline in different degrees in the near future,indicating that the treatment is effective;4.Accurate HIPEC treatment is relatively safe and feasible,and has little effect on the patient’s vital signs such as body temperature,heart rate,blood pressure,respiration,blood sample saturation,and is basically within the normal range;5.The incidence of adverse reactions and complications were low.Bone marrow transplantation did not occur.After symptomatic treatment illness can be relieved.Therefore,clinical safety is viable.