Effect Of Salt Intake On Urine Protein And Left Ventricular Volume In Patients With Hypertension Index And Anp Gene Expression

Objective:Essential hypertension is caused by both genetic and environmental factors.Excessive salt intake in the diet is one of the factors that contribute to the development of hypertension.It is well known that the sensitivity of blood pressure to salt intake is different in patients with essential hypertension.The pathogenic factors of salt-sensitive primary hypertension vary and interact with each other.Aging,weight changes,living conditions,eating habits,etc.can change the salt sensitivity of hypertension.In contrast,secondary salt-sensitive hypertension is caused by a specific,identifiable cause.Recent studies have elucidated the mechanism of the onset of primary salt-sensitive hypertension.To evaluate the effect of salt intake on urine protein,left ventricular mass index and atrial natriuretic peptide(ANP)gene expression in hypertensive patients,and provide evidence for the prevention and treatment of hypertension.Methods:183 high blood pressure patients from Tianjin General Hospital were selected as the study subjects,and systolic blood pressure and diastolic blood pressure were measured at the time of quiet.Divided into low-salt,mid-salt,and high-salt diet groups,the urinary sodium content was different in each group.Urine protein content was measured,echocardiography,and real-time fluorescence quantitative polymerase chain reaction(Real-time PCR)were performed.The expression of ANP gene was detected.SPSS22.0 software package was used for statistical analysis.The comparison among groups of measurement data was analyzed by analysis of variance,and the comparison of groups of count data was performed byχ2 test.Result:The level of urinary protein in the high salt diet group[(197.27±121.87)mg/L]was significantly higher than that in the low salt diet group[(121.46±54.46)mg/L]and the medium diet group[(146.41±93.81)g/m~2](p<0.05),the left ventricular weight index was significantly higher in the high-salt diet group[(187.5±79.24)g/m~2]than in the low-salt diet group[(149.86±63.99)g/m~2](p<0.05),and there was no significant difference compared with the medium diet group[(155.1±72.07)mg/L],The expression level of ANP gene in blood of patients with high salt diet(1.82±0.11)was significantly higher than that of medium group(1.43±0.09)(p<0.05).The expression level of ANP gene in blood of low salt diet group(0.95±0.08)was significantly lower than that of medium group(p<0.01).Conclusion:The results showed that hypertensive salinity intake leads to elevated blood pressure.When salt intake increases,the urinary protein content of hypertensive patients will increase,and the left ventricular mass index will increase and the ANP expression level will increase.Symptoms of hypertension and increased damage to target organs.Therefore,in the case of hypertensive patients,controlling salt intake can help control blood pressure levels and relieve hypertension’s damage to target organs,which is especially important in improving the prognosis.