| Objective This study retrospectively analyzed the correlation between serum uric acid(SUA)level and left ventricular mass index(LVMI)in hypertensive patients,so as to provide reference for clinical practice.Methods This study was a cross-sectional study.Adult(agefrom18 to 75years)hypertensive patients(SBP≥140mmHg and(or)DBP≥90mmHg)whoadmitted between January 1,2016 and December 30,2016 from the First Affiliated Hospital of Guangxi Medical University Cardiology were included in the present analysis.We collect clinical patients’ data.Venous blood samples were taken from all patients within 24 hours after admission.According to the SUA levelon admission,all patients were divided into four groups,whichthe first group had 30 patients with SUA levels ranging from 103 mol/L to 327mol/L,the second group had 30 patients with SUA levels ranging from 327mol/L-551 mol/L,the SUA level of the third group which had 29 patients was551 mol/L-755 mol/L,and the level of SUA in the fourth group was 755 mol/L-999 mol/L,including 31 patients.Then through using the Odds ratio(OR)and95% confidence interval(95%CI)carries on the comparison to the results,weobserved the relationship between SUA level and LVMI in patients with hypertension.Results A total of 120 patients with hypertension were included in this study,including 45 females and 75 males,with a female to male ratio of 1:1.6and an average age of 62.81±12.00 years.Univariate analysis showed age(OR=-0.93,95%CI :-1.74 to-0.13),diastolic blood pressure(OR=0.74,95% CI:0.15 to 1.34),creatine kinase(OR=-0.04,95% CI:-0.07 to 0.00),creatine kinase isomer-MB(OR=-0.44,95%CI:-0.82 to-0.05),aortic root diameter(OR=3.47,95%CI: 0.34),left atrial diameter(OR=3.24,95%CI: 1.96 to 4.60),left ventricular end-diastolic diameter(OR=3.74,95%CI: 2.96 to 4.52),left ventricular end-systolic diameter(OR=2.54,95%CI: 1.86 to 3.23),left ventricular posterior wall thickness(OR=13.91,95%CI: 9.15 to 18.67),right ventricular diameter(OR=2.69,95% CI: 0.49 to 4.90),right ventricular outflow tract(OR=4.00,95%CI: 1.48 to 6.51),main pulmonary artery diameter(OR=4.90,95%CI: 2.07 to 37.74)was associated with LVMI in patients with hypertension(P<0.05),while gender,height,weight,systolic blood pressure,smoking,drinking,body mass index,white blood cell,platelet,total cholesterol,triglyceride,LDL cholesterol,HDL cholesterol,interventricular septal thickness and other factors were not significantly different(P>0.05).In theunivariate analysis of SUA levels grouping and LVMI in hypertensive patients,the second group was compared with the first group(OR=19.83,95%CI:-5.96 to 45.62,P=0.1346),the third group was compared with the first group(OR=24.22,95%CI:-1.80 to 50.23,P=0.0706),and the fourth group was compared with the first group(OR=58.40,95%CI:-5.96 to 45.62,P=0.1346).With the increase of SUA level,the OR value was > 1 and showed an increasing trend,and the P value gradually decreased to < 0.05.In Logistic multiple regression analysis,after adjusting the univariate analysis of meaningful variables(age,diastolic pressure,aortic root diameter,left atrium diameter,left ventricular end systolic diameter,right ventricular diameter,right ventricular outflow tract,and the main pulmonary artery diameter,etc.),the results showed that in the four SUA groups,the second group wascompared with the first group(OR=9.69 in,95%CI:-11.27 to 0.66,P=0.3666),The third group wascompared with the first group(OR=6.19,95% CI:-15.07 to 7.44,P=0.5695),and the fourth group wascompared with the first group(OR=28.79,95%CI: 6.28 to 51.01,P=0.0125 < 0.05).With the increase of SUA level,it can still be seen that the OR value of > 1 is on the rise,and the P value gradually decreases to < 0.05.Conclusion Our study showed that there was a linear correlationbetween SUA level and LVMI in hypertensive patients,and the higher SUA level is,the higher the LVMI is. |
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