Efficacy Of Preoperative Neoadjuvant Chemotherapy And Surgery Alone For Colon Cancer: A Meta-analysis

Objective To compare the efficacy of preoperative neoadjuvant chemotherapy with surgery alone for colon cancer.Methods The databases included PubMend?EMbase?COchrane Library?CNKI were retrieved?And the studies about the comparison of efficacy between preoperative neoadjuvant chemotherapy(neoadjuvant group)and surgery alone(surgery group)for colon cancer were collected.The quality of included studies was assessed,and the data were collected.Then the Meta-analysis was performed to compare the efficacy of neoadjuvant chemotherapy with that of surgery aloneResults Ten studies were involved,which consisted of 3159 patients.Meta-analysis showed that there was no significant difference in the 5-year overall survival(RR=1.04,95%CI:0.99?1.10,P=0.13),5-year disease-free survival(RR=0.97,95%CI:0.91?1.05,P=0.49),recurrence(RR=0.81,95%CI:0.54?1.22,P=0.32),anastomotic leakage(RR=1.90,95%CI:0.72?5.04,P=0.20)or rate of abdominal infection(RR=1.07,95%CI:0.70?1.64,P=0.76)between neoadjuvant group and surgery group,Compared to surgery group,tumor diameter was reduced(MD:-0.24,95%CI:-0.41?-0.06,P=0.009),R0 resection rate improved(RR=1?10,95%CI:1.05?1.16,P<0.0001),metastasis reduced(RR=0.66,95%CI:0.50?0.86,P=0.002).3-year overall survival improved(RR=1.07,95%CI:1.01?1.12,P=0.01)in the neoadjuvant group.Conclusion Neoadjuvant chemotherapy can reduce tumor diameter,improve R0 resection rate,improve 3-year overall survival,reduce recurrence and metastasis for colon cancer,but have no differences in anastomotic leakage,rate of abdominal infection,5-year overall survival,5-year disease-free survival.