| Purpose:The objective of the present meta-analysis was to analyze efficacy and safety of postoperative chemoradiotherapy after surgery for gastric cacer,and establish a consensus on whether it is suitable for the patients.Methods:We searched Chinese Journal Full-text database retrieval, VIP database, Chinese Biomedical Literature Database; Cochrane Library, PubMed and EMBASE (retrieved as of the date of June 2014), in relevant Gastric Cancer postoperative radiotherapy combined with chemotherapy and chemotherapy alone in randomized controlled trials (randomized controlled trial RCT), the evaluation of the methodological quality of the included studies, summarizing data using RevMan5.2 and Stata 12.0 software for analysis and evaluation.3-year survival rates were compared; 3,5 years of disease progression-free survival (Progression-free survival PFS),5-year overall survival (Overall survival OS), and treatment-related gastrointestinal reactions, bone marrow suppression, hand-foot syndrome and other adverse reactions indicators.Results:A total of 1143 patients from 11 randomized controlled trials were identified for this meta-analysis. Our results showed that postoperative chemoradiothrapy can improved inl-year Survival[RR=1.20(95%CI:1.10～1.30)],2-years Survival [RR=1.34(95% CI:1.16～1.56)], 3-years Survival [RR=1.57(95%CI:1.27-1.86)]and 3-years DFS [RR=1.10 (95%CI:1.00-1.21)],5-years DFS [RR= 1.27(95%CI:1.02-1.60)],5-years OS[RR= 1.24(95%CI:1.01-1.51)]. The main grade 3 or 4 toxicities in Nausea, Anorexia, Hand-foot syndrome and Myelosuppression were equivalent between the two groups.Conclusion:From the results of our study,In resected gastric cancer adjuvant Chemoradiotherapy Improve survival in gastric cancer patients benefit more obvious, and with chemotherapy-related adverse events did not significantly increased. |
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