Analysis Of Clinicopathologic Factors And Prognosis Of 265 Cases Of Small Cell Carcinoma Of The Cervix

Objective: To retrospectively analyze the clinic-pathologic features therapeutic efficacy of different treatment options and prognosis of 265 cases of small cell carcinoma of the cervix.Methods: Using chi-square test or Fisher exact test to analyze the correlation between the clinical factors and the difference in prognosis of various treatment options;Kaplan-Meier method to complete the plotting of survival curve,log-rank test to compare the survival difference;Cox proportional hazards model was applied for univariate and multivariate survival analysis.IBM SPSS Statistics 24 software package was used for statistical analysis.P < 0.05 was statistically significant.Results: Univariate analysis showed that FIGO stage and Lymph node metastasis had effect on DFS(p=0.000)(p=0.020)and OS(p=0.005)(p=0.041).Multivariate analysis indicated that FIGO stage was an independent risk factor for disease-free survival(HR 3.050 95%CI 1.529-6.083 p=0.002)and overall survival(HR 2.170 95%CI 1.074-4.383 p=0.031).The analysis clearly stated that for the early stage of patients,the effect of B and C two treatment modalities on the certainly recrudescence were different(p=0.048).Moreover,further exploration showed that the differences were mainly reflected in the prognosis of recurrence(p=0.043)between the treatment of “NACT combined with surgery followed by adjuvant therapy” and “Surgery combined with postoperative adjuvant therapy”.However,there were no significant difference in the prognosis of patients whether treated with postoperative adjuvant therapy or not,just as the effect of postoperative adjuvant chemotherapy and adjuvant radio-chemotherapy on the prognosis(p>0.05).For the patients with advanced stage,those who had received chemotherapy(n=20)compared with those no chemotherapy(n=9),or had radiotherapy(n=9) compared with no radiotherapy(n=20),or surgery(n=24)with no surgery(n=5),they all had no difference in the outcome.And there were also no significant differences between the three treatments when talking about the impact on the prognosis of survival(p>0.05).Conclusions: Multivariate analysis showed that FIGO stage was an independent risk factor for DFS(HR 3.050 95%CI 1.529-6.083 p=0.002)and OS(HR 2.170 95%CI 1.074-4.383 p=0.031).There was no significant difference in survival between the three treatment regimens whether early or advanced patients.For some patients with early stage,the effect of neoadjuvant chemotherapy on the prognosis of recurrence was different from that of no neoadjuvant chemotherapy(p=0.043).