| Objectives In this study,patients with acute pancreatitis were split into different treatment options which contains general therapy,rhubarb,salvia miltiorrhiza injection and combined treatment.Differences in efficacy of different treatment options for acute pancreatitis were analyzed by collecting the symptoms,signs,and test results of normal time and imaging findings.At the same time to some extent to explore the pathological mechanism of acute pancreatitis.Methods This study choose 132 patients from September 1~stt 2016 to December 31~stt 2017 in the Department of Gastroenterology and critical care medicine of north China university of science and technology affiliated hospital who were diagnosed acute pancreatitis.All patients met the Guidelines for diagnosis and treatment of acute pancreatitis in China.The patients was divided into four groups according to the time of admission:general treatment group,combined rhubarb treatment with the first group,combined salvia miltiorrhiza injection with the first group,and the group which contains all the measures above.CT results were collected on the day of admission and 7 days after admission,and four groups of CTSI values results were recorded separately.As the time goes,sign the length of the time of abdominal pain,abdominal distention,defecation.Mark the time of the recovery time of blood amylase,blood lipase,white blood cell count,blood neutrophil count and the C-reactive protein.The SPSS 17.0 software package was used to analysis all the data above.Measured data with normal distribution were expressed as mean±standard deviation.The pairwise comparisons among multiple groups were compared by using single-factor analysis of variance,percentages was used to express the count data(%),the difference between the two groups was compared byχ2 test;It means the difference was statistically significant when P<0.05,and the test level wasα=0.05.Results 1 There was no significant difference among the groups in gender,age,white blood cell count(WBC),blood neutrophil count(NEUT),C-reactive protein(CRP)and CTSI(P<0.05).2 After the treatment,the time(h)when the abdominal pain of the four groups disappearance were respectively 114.70±14.44,82.12±13.54,100.03±18.10,65.97±8.57,the time(h)when abdominal distention disappearance were 154.00±17.46,125.06±19.01,136.91±22.99,and 102.73±15.59,all the data of the groups were confirmed statistically significant(P<0.05);the first cacation(d)were respectively 5.10±1.41,3.81±1.05,4.50±1.36,and 3.25±0.84,it seems the differences were significant between the combined medication group and the others(P<0.05),the difference between the rhubarb group and the general group also exist significant(P<0.05).The recovery time(d)of WBC was 6.13±1.76,5.40±1.69,4.70±1.46,3.96±1.13,the difference between the general treatment group and the rhubarb treatment group,the salvia miltiorrhiza injection group and the combined medication group were not statistically significant(P>0.05),the rests were statistically significant(P<0.05);The recovery time(d)of NEUT count were respectively5.48±1.51,5.16±1.20,4.28±0.87,and 4.06±0.79,the differences were statistically significant among all the groups except the one between the general treatment group and the rhubarb treatment group,the one between salvia miltiorrhiza injection group and the combined medication group(P>0.05).The recovery time(d)of C-reactive protein were respectively 6.37±1.21,6.12±1.22,5.64±0.99,and 5.46±0.87,the statistically significanted difference only appeared between the general treatment group and statistically significant,the general treatment group and the combined medication group(P<0.05).CTSI score was collected after one week treatment and respectively were 2.69±0.84,2.30±0.63,1.93±0.82,1.66±0.73.There difference compared with before admission was statistically significanted,and the differences between the salvia miltiorrhiza injection group and the combined medication group,the general treated group and the rhubarb treatment group were not statistically significant,the others were statistically significant(P<0.05).Conclusions 1 All the four treatment options are effective for acute pancreatitis.2 The application of rhubarb and salvia miltiorrhiza injection can significantly reduce abdominal pain,bloating and defecation time of patients,and rhubarb is superior to salvia miltiorrhiza injection for recovery of intestinal function and self-perception of patients.The combination of the two is the most effective.3 Salvia miltiorrhiza injection can reduce blood inflammatory cells in patients,and rhubarb has no significant effect on blood inflammatory index.4 The application of rhubarb and Salvia miltiorrhiza injection can promote the recovery of the imaging performance of patients.Salvia miltiorrhiza injection is superior to the rhubarb.The combination of the two is the most effective. |
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