| Depression disorder is a kind of mood disorder with high prevalence,high disease burden,high recurrence rate,and high disability.It is mainly manifested in significant and persistent depressive state.61.8%of depressive patients are accompanied by different severity.Insomnia is characterized by increased sleep latency,decreased sleep efficiency/maintenance,and increased awakening time/frequency.The causes of depressive disorders are complex.Although antidepressant drugs for a certain etiological cause can alleviate some symptoms,the effectiveness of all existing antidepressants does not exceed 70%,and it takes 2 to 6 weeks to achieve its efficacy.Taking into account a variety of pathogenic factors,antidepressant drugs generally have the disadvantages of the need to improve efficacy,delayed onset of action,and ineffective treatment of some cases.The combination of traditional Chinese and Western medicine treatment not only exerts strong anti-depressant drugs on certain pathological changes,but also brings into play the overall adjustment of Chinese medicine and the characteristics of adapting to people.Clinically,it has shown a complementary effect of rapid onset of action and high efficacy.Objective:In this study,selective 5-HT and NE reuptake inhibitors were used to treat depressive disorders associated with insomnia.Clinical studies on 104 patients were conducted to evaluate the efficacy and safety of modified Chaihu Guizhi Decoction combined with venlafaxine in the treatment of depressive disorders associated with insomnia.In particular,flavored Chaihu Guizhi Decoction improves the symptoms of insomnia and reduces the side effects of antidepressants.Method:Depression with 104 insomnia patients were selected,97 trials were completed,49 patients in the treatment group and 48 in the control group.The treatment group received venlafaxine basic therapy,plus flavored Chaihu Guizhi Decoction and the control group only venlafaxine alone.The tablets were delivered for 8 weeks.The HAMD-17 and SDS were used in the two groups before treatment and on the 1st,2nd,4th,6th,and 8th weekend of treatment.Pittsburgh Sleep Quality Index(PSQI)was used before treatment,4 and 8 weeks after treatment,and efficacy and safety were assessed by SERS on the 8th weekend.The course of treatment was 8 weeks.Depression and sleep were observed before and after treatment.Changes in the indicator.Result:After statistical analysis,there was no significant statistical difference between the two groups in terms of sex,age,education level,marital status,and scales before treatment,which were comparable.At the time points of 1,2,4,6 and 8 weeks of treatment,the scores of HAMD-17 and SDS scales in the treatment group were better than those in the control group(P<0.05).The depression cure rate in the treatment group was 28.6%,and the effective rate was 95.6%.The cure rate in the group was 10.4%;the effective rate was 68.8%.The cure rate and effective rate in the treatment group were higher than those in the control group(P<0.05).After treatment(4th and 8th weeks),the PSQI score of the treatment group was better than that of the control group(P<0.05).The cure rate of the control group was 30.6%,and the cure rate of the control group was 12.5%.The cure rate of the treatment group was higher than that of the control group.Group(P<0.05);After treatment,the treatment group relieved the side effects of venlafaxine in different degrees,and relieved the adverse reactions such as dry mouth,constipation and sexual dysfunction,etc.,better than the control group(P<0.05).Conclusion:1.Modified Chaihu Guizhi Decoction combined with venlafaxine has definite curative effect in the treatment of depressive disorder with insomnia.Modified Chaihu Guizhi Decoction improves antidepressant efficacy and improves insomnia symptoms.2.The combination of Chaihu Guizhi Decoction and venlafaxine in the treatment of depressive disorder with insomnia can alleviate various symptoms caused by side effects of antidepressants. |
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