Clinical Significance Of SIRT1 Expression In Invasion And Metastasis Of Esophageal Squamous Cell Carcinoma

Objective:To observe the expression of silent information regulator 1(SIRT1)in esophageal squamous cell carcinoma(ESCC),and its relationship with invasion and metastasis of esophageal squamous cell carcinoma and its effect on survival and prognosis.Methods:The clinical and pathological data of 104 patients with esophageal cancer who underwent radical esophagectomy at the Affiliated Tumor Hospital of Xinjiang Medical University from January to December 2009 were retrospectively reviewed.Immunohistochemical method(EnVision method)was used to detect the expression of SIRT1 in cancer tissues and adjacent tissues.The clinicopathological features of different SIRT1 expression were compared.The factors affecting the prognosis of the patients with esophageal cancer were analyzed.Results:The positive expression rate of SIRT1 protein was significantly higher in esophageal squamous cell carcinoma tissues than that in adjacent tissues[61.54%(64/104)vs.29.81%(31/104),χ~2=21.10,P<0.05].The expression of SIRT1 in esophageal squamous cell carcinoma was significantly correlated with vascular infiltration(VI),infiltration depth(pT),lymph node metastasis(pN)and clinical stage(pTNM)(P<0.05).Univariate survival analysis showed that the overall survival rate was significantly lower in patients with SIRT1 positive expression than that of patients with negative expression(Log-rankχ~2=10.065,P<0.05).SIRT1 positive expression,lymph node metastasis,deeper depth of invasion,late clinical stage and vascular infiltration showed poor prognosis(P<0.05).Cox multivariate regression analysis showed that SIRT1 positive expression,lymph node metastasis,depth of invasion and clinical stage were independent prognostic factors for esophageal squamous cell carcinoma.The prognosis of patients with deep tumor invasion,lymph node metastasis,clinical stage late and high expression of SIRT1 was worse.Conclusion:SIRT1 is highly expressed in esophageal squamous cell carcinoma and which is closely related to the invasion and metastasis of esophageal squamous cell carcinoma and has an effect on the prognosis of patients.