| Objectives:To compare Topcon,Optovue and Zeiss three kinds of optical coherence tomography angiography technology in the application of the patients with retinal vein occlusion by measured optical coherence tomography angiography image vessel density of retinal superficial capillary plexus and the deep capillary plexus,the area of the foveal avascular zone,the FAZ boundary definition and motion artifacts rate。Methods:Retrospective study.We collected 32 RVO patients from June 2017 to September 2017 in the Department of Ophthalmology,First Affiliated Hospital of Kunming Medical University,including 22 patients with central retinal vein occlusion and 10 patients with branch retinal vein occlusion,.a retinal scan of 32 RVO patients(32 eyes)was performed on the same day by the same person using Topcon,Optovue,and Zeiss OCTA devices(Topcon DRI-OCT SS-OCT,Optovue,and Zeiss 5000-HD-OCT).OCT-A examinations were performed using a 3 × 3mm and 6 ×6mm volume scan pattern centered on the fovea.Then compare the two types(Topcon and Optovue 32 cases(CRVO 22 eyes,BRVO 10 eyes),Optovue and Zeiss 21 cases(CRVO15 eyes,BRVO6 eyes),Topcon and Zeiss 21 cases(CRVO15 eyes,BRVO6 eyes))three kinds of OCTA imaging VD of retinal superficial capillary plexus and the deep capillary plexus,FAZ,FAZ boundary definition and motion artifact rate,where VD,FAZ were evaluated using imageJ software.Results:Macular area 3×3mm volume scan pattern OCTA image:Topcon OCTA Com pares with Optovue OCTA:1.Significant differences in vessel density between superficial and deep retinal capillary plexus(SCP:45.94± 5.63%VS 38.88±12.87%,P<0.05;DCP:49.39±6.45%VS 40.45±2.93%,P<0.05),however,the consistency of the superficial and deep capillary plexus vessel density measurement results were all P>0.05,indicating that the measurement system error is large and the consistency is weak.2.The difference of FAZ area measured by two OCTA was statistically significant(0.28±0.11 vs 0.19±0.06,P<0.05)but the consistency is weak,P>0.05.3.The motion artifact rates of the two OCTA superficial capillary plexus OCTA images was 23.53%and 41.18%,respectively,and the motion artifact rates of the two OCTA deep capillary plexus OCTA images was 41.18%and 47.06%,respectively,however,there was no significant difference in motion artifact rates between superficial and deep OCTA images,P>0.05.4.The FAZ boundary resolution of the two OCTA superficial capillary plexus OCTA images was 93.75%and 87.5%,and the FAZ boundary resolution of the two OCTA deep capillary plexus OCTA images was 75%and 81.25%,however,there was no significant difference in FAZ boundary resolution between superficial and deep OCTA images,P>0.05.Zeiss OCTA compares with Optovue OCTA:1.Significant differences in vessel density between superficial and deep retinal capillary plexus(SCP:13.55 ±1.33%VS 39.04±3.33%,P<0.05;DCP:15.84± 1.92%VS 39.25±3.04%,P<0.05),however,the consistency of the superficial and deep capillary plexus vessel density measurement results were all P>0.05,indicating that the measurement system error is large and the consistency is weak.2.There was no statistically significant difference in FAZ area measured by the two OCTA(0.30±0.16 vs 0.20±0.07,P>0.05).3.The motion artifact rates of the two OCTA superficial capillary plexus OCTA images was 33.33%and 42.86%,respectively,and the motion artifact rates of the two OCTA deep capillary plexus OCTA images was 57.14%and 42.86%,respectively,however,there was no significant difference in motion artifact rates between superficial and deep OCTA images,P>0.05.4.The FAZ boundary resolution of the two OCTA superficial capillary plexus OCTA images was 100%and 85.71%,and the FAZ boundary resolution of the two OCTA deep capillary plexus OCTA images was 71.43%and 85.71%,however,there was no significant difference in FAZ boundary resolution between superficial and deep OCTA images,P>0.05.Topcon OCTA compares witih Zeiss OCTA:1.Significant differences in vessel density between superficial and deep retinal capillary plexus(SCP:46.300±2.88%VS 13.55±1.33%，P<0.05;DCP:50.42±3.27%VS 15.84± 1.92%,P<0.05),however,the consistency of the superficial and deep capillary plexus vessel density measurement results were all P>0.05,indicating that the measurement system error is large and the consistency is weak.2.There was no statistically significant difference in FAZ area measured by the two OCTA(0.35±0.12 vs 0.30±0.16,P>0.05).3.The motion artifact rates of the two OCTA superficial capillary plexus OCTA images was 14.29 and 33.33%,respectively,and the motion artifact rates of the two OCTA deep capillary plexus OCTA images was 42.86%and 57.14%,respectively,however,there was no significant difference in motion artifact rates between superficial and deep OCTA images,P>0.05.4.The FAZ boundary resolution of the two OCTA superficial capillary plexus OCTA images was 85.71%与 100%,and the FAZ boundary resolution of the two OCTA deep capillary plexus OCTA images was 85.71%与 71.43%,however,there was no significant difference in FAZ boundary resolution between superficial and deep OCTA images,P>0.05.Macular area 6x6mm volume scan pattern OCTA image:Topcon OCTA compares with Optovue OCTA:1.Significant differences in vessel density between superficial and deep retinal capillary plexus(SCP:43.72±3.39%VS 52.58±6.56%,p<0.05;DCP:45.81±4.37%VS 60.32±3.33%,p<0.05),and the consistency test was performed for the measurement results of superficial and deep capillary plexus vessel density,P<0.05,the consistency was good.2.The difference in FAZ area measured by the two OCTA was statistically significant(0.23±0.09 vs 0.19±0.05,P<0.05),and the consistency was better,P<0.05.3.The motion artifact rates of the two OCTA superficial capillary plexus OCTA images was 18.75 and 50%,respectively,and the motion artifact rates of the two OCTA deep capillary plexus OCTA images were 43.75%,however,there was no significant difference in motion artifact rates between superficial and deep OCTA images,P>0.05.4.The FAZ boundary resolution of the two OCTA superficial capillary plexus OCTA images was93.75%and 75%,and the FAZ boundary resolution of the two OCTA deep capillary plexus OCTA images was 75%and 18.75%,however,there was no significant difference in FAZ boundary resolution between superficial and deep OCTA images,P>0.05.Zeiss OCTA compares with Optovue OCTA:1.Significant differences in vessel density between superficial and deep retinal capillary plexus(SCP:21.11±1.74%VS 44.86±2.70%,P<0.05;DCP:24.47±1.08%VS 45.90±2.66%，P<0.05),however,the consistency of the superficial and deep capillary plexus vessel density measurement results were all P>0.05,indicating that the measurement system error is large and the consistency is weak.2.The difference in FAZ area measured by the two OCTA was statistically significant(0.45±0.24 vs 0.21±0.07,P<0.05),and the consistency was better,P<0.05.3.The motion artifact rates of the two OCTA superficial capillary plexus OCTA images was28.57%and 42.86%,respectively,and the motion artifact rates of the two OCTA deep capillary plexus OCTA images was 57.14%and 42.86%,however,there was no significant difference in motion artifact rates between superficial and deep OCTA images,P>0.05.4.The FAZ boundary resolution of the two OCTA superficial capillary plexus OCTA images was100%and 85.71%,and the FAZ boundary resolution of the two OCTA deep capillary plexus OCTA images was 57.14%and 100%,however,there was no significant difference in the resolution of the FAZ boundaries between the superficial capillary plexus OCTA images,P>0.05,there was a statistically significant difference between the FAZ boundaries of deep capillary plexus OCTA images,P<0.05.Topcon OCTA compares with Zeiss OCTA:1.Significant differences in vessel density between superficial and deep retinal capillary plexus(SCP:53.87±2.88%VS 21.11±1.74%,P<0.05;DCP:58.96±2.94%VS 24.47± 1.08%,P<0.05),however，the consistency of the superficial and deep capillary plexus vessel density measurement results were all P>0.05,indicating that the measurement system error is large and the consistency is weak.2.The difference in FAZ area measured by the two OCTA was statistically significant(0.23±0.10 vs 0.45±0.24,P<0.05,P<0.05),and the consistency was better,P<0.05.3.The motion artifact rates of the two OCTA superficial capillary plexus OCTA images was14.29%and 28.57%,respectively,and the motion artifact rates of the two OCTA deep capillary plexus OCTA images was 28.57%and 57.14%,however,there was no significant difference in motion artifact rates between superficial and deep OCTA images,P>0.05.4.The FAZ boundary resolution of the two OCTA superficial capillary plexus OCTA images was85.71%and 100%,and the FAZ boundary resolution of the two OCTA deep capillary plexus OCTA images was 85.71%and 57.14%,however,there was no significant difference in FAZ boundary resolution between superficial and deep OCTA images,P>0.05.Conclusion:Three different OCTA devices have their own advantages and disadvantages in clinical applications.From the parameters of our experimental study,the OCTA images of 3 × 3mm and 6 × 6mm volume scan pattern centered on the fovea of patients with retinal vein occlusion,Topcon OCTA compares with Optovue OCTA,In the SCP and DCP,Topcon OCTA provides a higher number of images and an image with less motion artifacts for analysis;Zeiss OCTA compares with Optovue OCTA,In the SCP Zeiss OCTA provides a higher number,less motion artifacts,and a clearer image of the FAZ boundary for analysis,but in the DCP,Optovue OCTA is better than Zeiss OCTA;When Topcon OCTA compares with Zeiss OCTA,In the SCP Zeiss OCTA provides a higher number,less motion artifacts,and a clearer image of the FAZ boundary for analysis,While in the DCP Topcon OCTA provides a higher number,less motion artifacts,and a clearer image of the FAZ boundary for analysi.In the SCP,the boundary of FAZ is most recognizable in Zeiss OCTA;but in the DCP,the boundary of FAZ is most recognizable in Optovue OCTA. |
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