The Study Of Diffusion Kurtosis Imaging And Resting-state FMRI On Dorsal Attention Network In Alcohol Dependent Patients

Part I A voxel-based diffusion kurtosis imaging study of whole-brain in alcohol dependent patientsObjective To study the changes of micro structure of white matter and gray matter in alcohol dependent patients by using diffusion kurtosis imaging(DKI)based on the method of voxel-based analysis.Methods Thirty alcohol dependent individuals and twenty healthy control volunteers,matched in gender,age,handedness and education,were enrolled as the alcohol dependent group and control group respectively from September 2016 to June 2017.Michigan alcoholism screening test(MAST)was performed for all subjects.All the subjects underwent DKI data acquisition by MR scanning.The relevant parameters were obtained by DKE software,including fractional anisotropy(FA),mean diffusivity(MD),axial diffusivity(AD),radial diffusivity(RD),mean kurtosis(MK),axial kurtosis(AK),radial kurtosis(RK),FA of kurtosis(FAK).Independent sample t-test was performed to evaluate the significant difference of DKI parameters of two groups,meanwhile,the correlation analysis was conducted in DKI parameter values of different brain regions and MAST scores.Results Compared with the healthy control group,the FA value,MK value and RK value were decreased while the RD value was increased in alcohol dependence group,and there was significant difference between the two groups respectively(P<0.001).There was no significant difference between the two groups in the other parameters(AD,MD,AK,FAk).Compared with the healthy control group,the FA values of left lingual gyrus(164 voxels,t=-5.5818)and left hippocampus(38 voxels,t=-3.6642)increased,the MK value of left cerebellum posterior lobe(71 voxels,t=-4.0039)reduced,the RK value of left cerebellum posterior lobe(67 voxels,t=-4.1741),left middle cingulum(32 voxels,t=-3.9248),left superior parietal gyrus(36 voxels,t=-3.8123)reduced,and the RD value of the left inferior parietal gyrus(31 voxels,t=3.7314)increased in alcohol dependence group.There was no correlation between MAST score and the value of DKI parameters(P>0.05).Conclusion There are dominant areas of brain injury in patients with alcohol dependence.The DKI parameters can reflect the changes of the whole brain microstructure of alcohol dependent patients and provide imaging basis in the diagnosis of alcohol dependence.Part II An independent component analysis of dorsal attention network in alcohol dependence patientsObjective To study the changes of dorsal attention network(DAN)in alcohol dependent patients by using functional magnetic resonance imaging(fMRI)based on independent component analysis(ICA),and to explore its role in the mechanism of attentional dysfunction.Methods Thirty three alcohol dependent individuals and twenty one healthy control volunteers,matched in gender,age,handedness and education,were enrolled as the alcohol dependent group and control group from September 2016 to June 2017.Michigan alcoholism screening test(MAST)was performed for all subjects.All the subjects underwent fMRI data acquisition by MR scanning.The dorsal attention network was extracted by independent component analysis.Independent sample t-test was performed to evaluate the significant difference of two groups,meanwhile,the correlation analysis was conducted in the different brain regions and MAST scores.Results In the resting state,compared with healthy control group,the alcohol dependence group showed no functional connectivity increased in brain,the functional connectivity of the right inferior parietal lobule(42 voxels,t=-5.1477),right supramarginal gyrus(35 voxels,t=-4.4603),right middle frontal gyrus(17 voxels,t=-4.0956),left superior parietal gyrus(11 voxels,t=-3.8545)and left precentral gyrus(18 voxels,t=-4.2176)were significantly decreased in alcohol dependent patients.The significantly decreased regions showing no correlation with the MAST scores(P>0.05).Conclusions In the resting state,The functional connectivity of the dorsal attention network was decreased in alcohol dependent patients.Resting-state brain functional magnetic resonance imaging(fMRI)can reflect the changes of brain function,and also provides a imaging basis for the mechanism of addiction and behavioral cognitive abnormality in alcohol dependent patients.