Prelininary Study Of Chronic Alcohol Dependence In Patients With Brain Reward Loopstructure MRI

Objective selection for early clinical diagnosis and assessment of effi-caey by determining the characteristics of the CAD crowd brain reward loopbr ain lesions in MRI valuable radiographic parameters.Materials and methods Into30CAD patients and MAST scale score id divided intu mild and severe degrees into30age-and sex-matched healthy v olunteersserved as controls.All subjects were PHILIPS Achieva1.5T supercondu ctive magnetic resonance imaging system,16-channel standard head and neck jo intcoil,scanning30normal controls and30cases of60patients.Check the sequ ence include:1、Whole brain conventional horizontal axis T1WI,T2WI,DWI and sagittal T1WI.2、Three-dimensional fast spoilde gradient acho sequence (3D-FF E)coronary bit T1WI.3、DTI SE-EPI sequence.Loop in the convertional sequenc e evaluation reward-related brain areas morphological characteristics and detenu ination of the frontal lobes,corpus callosum,corpus callosum pressure fo the ant erior branch of the internal capsule,posterior branch of the internal capsule,the thalamus and the nucleus accumbens FA values.TO PHILIPS supplied software relatde post-processing MRI WORK SPACE EXTENDED MRI2.6.3.1DTT im aging.By two physicians blinded evaluation,qualitative results are descriptive Ian guage and consensus.SPSS19.0statistical analysis software,the measurement res ults using the test,count the results of X2test,P<0.05for the difference was st atistically significant.Results30CAD patients brain atrophy, white matter degeneration higher inc idence of abnormalities, and brain atrophy in patients with frontal lobe atrophy.30patients with chronic alcohol dependenceand health groups nucleus accumbens a verage volume of the right side than the left (P<0.01) inpatients with chronic alco hol dependencenucleus accumbens average volume is greater than the healthy gro up nucleus accumbensvolume (P<0.01) statisticssignificance. Reward loop-relate d brain regions (frontal lobe,the corpus callosum and the pressure of the nucleus ac cumbens) FA values reduce drinkingfrequency times were significantly associated (P<0.01). Reduce early CAD Reward loop brain regions(frontal lobe, the corpus ca llosum and the press section, the nucleus accumbens) FA value was statistically sig nificant (P<0.05), non-rewardloop brain regions (anterior branch of the internal ca psule, posterior branchcentrum ovale) reduced FA value was not statistically signif icant, the advanced CAD reward loop and non-reward loop brain District FA values werereduced statistically significant (P<0.05).4cases (13.3%) of local thinning of th e whitematter fiberbundles.Bilateral symmetry structure FA values in the group no difference。Bilateral symmetry structure FA values in the group no differences in al1parts of the FA values between the two groups have more differencesCAD grou p FA values downward trend.CAD various parts of the FA value year-old drinkin g time, alcohol consumption increases the degree of alcoholism increase, a downwar d trend, regardless of age. Accumbens core volume CAD group than the control g roup.Conclusion Conventional MRI sequences Joint3D FFE sequence and DTI tec hnology for a comprehensive assessment of CAD brain structure and function dam age, has important application value. Chronic alcoholism can lead to ischemic brai n reward loop and related structures, degeneration, caused by nerve degeneration in advance, frontal and corpus callosum sensitive parts and as a sensitive indicator o f early diagnosis of CAD.