Study On The Incidence Of Cough Caused By Oxycodone During Induction Of General Anesthesia And Its Influence On Hemodynamics

ObjectiveTo investigate the effect of oxycodone and fentanyl with equivalent dose on the incidence and severity of cough and the related to hemodynamic indexes.To provide the evidence of opioid drugs for induction of general anesthesia.MethodsThis study included 240 patients who were scheduled to undergo elective surgery in Shandong Cancer Hospital from April 1st 2016 to December 1st 2017 with ASA(American Association of Anesthesiologists)Grade I-III.The patients were randomly divided into 3 groups with 80 cases in each group according to the order of operation by the table of random number.Patients received either oxycodone 0.25 mg/kg(group-O),fentanyl 2.5μg/kg(group-F)and equal volume of 0.9%normal saline(group-N)administered intravenously in 5s.Oxygen saturation(SpO2),Heart rate(HR)and Mean arterial pressure(MAP)before administration(Tl),the number of coughing(n)within 2 min after dosing,time for the first cough(s),and the datas of SpO2,HR,MAP on 2 min after dosing(T2)were all reccrded.Then,it’s time to intravenous other drugs were observed for general anesthesia induction.The severity of coughing was graded as no cough(0),mild(1-2),moderate(3-5)and severe(>5)according to the number of cough.Results(1)The incidence of cough was significantly lower in group O(8/77;10.4%)than group F(28/78;35.9%),The patients in group-N did not have a cough.(x2=39.095,P<0.001)(2)There was no significant difference between the group-0 and the group-F on onset time(group-O(30.4±7.9)s;group-F(25.8±5.8)s;t=1.800,P=0.081)and severity of Cough(group-O:mild 5,moderate 3,severe O;group-F:mild 8,moderate 17,severe 3;x2=3.347,P=0.067).(3)It found that there is a correlation on coughing incidence and age of cough in Group-F(OR,95%CI)=[0.922(0.873-0.974)];(4)Group-F has signficant reduction between T1 and T2 on MAP,HR and SpO2(P<0.05),group-0 has significant reduction between T1 and T2 on SpO2 and MAP(P<0.05).ConclusionThe equivalent of fentanyl and oxycodone were injected by intravenous for anesthesia induction,the incidence of cough induced by hydroxycodone was lower and the inhibition of respiration was less than fentanyl,but the hemodynamics was less affected.