A Clinical Study On Shenmai Injection In Children With Malignant Solid Tumor Treated With Chemotherapy

Objective: To study the effect of Shenmai Injection on the protection of bone marrow,reducing the toxic and side effects of chemotherapy,improving the short-term curative effect and the quality of life in children with malignant solid tumor treated with chemotherapy.Methods: 224 children with malignant solid tumor were randomly divided into control group and three dose gradient experimental groups,after four courses of treatment,the differences in the blood,liver and kidney function and side effects of chemotherapy,short-term efficacy and quality of life were evaluated between experimental groups and the control group.Results: There was no significant difference between three experimental groups and the control group in blood routine,liver function,renal function,heart function and side effects of chemotherapy(P>0.05).Experimental group 1(P=0.011)and experimental group 2(P=0.004)were significantly different from the control group in short-term curative effect,but there was no significant difference between experimental group 3 and control group(P=0.139).There was a significant difference in life quality between three experimental groups and the control group(P=0.000,0.003,0.001,respectively).Conclusions: Shenmai Injection has no significant improvement on the function of bone marrow,vital organs function and the side effects of chemotherapy in children treated with chemotherapy,otherwise it can help with the recovery of body during chemotherapy,improve the quality of life,make children able to tolerant and complete chemotherapy,improve the prognosis of children with malignant solid tumors.