Injection, Hydroxycamptothecin And Cyclophosphamide Antiangiogenic Heat Chemotherapy Experimental And Clinical Research

Part 1 The Research on ShenMai Injection, Hydroxycamptothecinand Cyclophosphamide Inhibiting Angiogenesis[Background] The growth of tumors is vessel-dependent. Tumors stimulate endothelial cells' proliferation and microvessels' formation by secreting some related factors, whereas blood vessels control tumors' growth through nutrition supply. Moreover, tumor blood vessels participate in the whole process of tumor development, including canceration, transmission of cancerous cells, formation of metastasis and its breakage. Therefore, anti-angiogenetic therapy has become one of the heat points in cancer research field. Some chemotherapeutics can inhibit selectivity the growth of new vascular endothelial cell observably in the way of low-dose and high time administration.. The growth of tumor cell will be retarded in short of blood supply. This is metronomic chemotherapy, or anti-angiogenic chemotherapy.Thermotherapy is an attractive addition to multidisciplinary approaches to clinical cancer treatment. The quantitative and reproducible effect of hyperthermia depends on the elevation of temperature and the duration of treatment. It has been reported that in vitro and in vivo hyperthermia can enhance the cytotoxic effect of certain anticancer drugs that have different mechanisms of action. Hyperthermia combined with chemotherapy is a logical and potentially powerful treatment. The magnitude of the enhancement varies according to different drugs and the scheduling of drugs with heat.Therapeutical principles of malignant tumor are strengthening body resistance, strengthening body resistance, strengthening body resistance, soften hard lumps and dispel nodes and treat the malignant with poisonous agents in traditional Chinese medicine. Recent study has revealed that some traditional Chinese drugs pharmaceutics have anti-angiogenetic ability, such as ShenMai Injection and hydroxycamptothecine.[ Objectives ] This experiment aims to â‘  study anti-angiogenetic ability of ShenMai Injection , hydroxycamptothecine and cyclophosphamide combined with...