Analysis Of The Cold- Or Heat- Syndrome Of Traditional Chinese Medicine Of Non-small Cell Lung Cancer Patients From The Characteristic Of The Lunula

ObjectTo investigate the characteristic of the lunula and the distribution of cold-and heat-syndromes of Traditional Chinese Medicine(TCM)in Nonsmall Cell Lung Cancer(NSCLC)patients.Then explore the relevance of the lunula characteristic with the cold-and heat-syndrome of TCM(the relevance including sensitivity and specificity).MethodsFor the eligible NSCLC patients,the information collected from patients with cold-and heat-syndrome of TCM according to the eight-principle syndrome differentiation,and the investigators checked it one by one to confirm eligibility information.Meanwhile,we record the type of the lunula.The data were collected,stablish the database,and calculate the data by SPSS 21.0 statistical software.After that,the correlation between the characteristic of the lunula and the cold-and heat-syndrome of TCM was analyzed,that is,the sensitivity and specificity of the characteristic of the lunula analyzed the cold-and heat-syndrome,and the influencing factors.Results1.The results of the characteristic of the lunula: A total of 312 copies of valid questionnaires,in 312 cases of NSCLC patients of the lunula type distribution:cold type 190 cases(60.9%),heat type 88 cases(28.2%),normal type 20 cases (6.4%),cold-heat complication type 14 cases(4.5%).The distribution of the lunula type of the difference with gender,age,pathological pattern had statistical significance(P<0.05).However,there was no significant difference in smoking or not,history of Chronic Obstructive Pulmonary Disease(COPD)or not,clinical stages,Epidermal Growth Factor Receptor(EGFR)gene Mutant or wild and history of surgery or chemotherapy(P>0.05).2.The results of the cold-or heat-syndrome type of TCM: In 312 patients,cold- syndrome 171 cases(54.8%)and heat-syndrome 141 cases(45.2%).3.The dialectical sensitivity and specificity of the lunula: As the dialectics of the eight principles as the standard,in general,the sensitivity and the specificity of the cold type lunula proof cold-syndrome was 87.7% and 71.6%.And,identification of heat-syndrome of the heat type lunula,the sensitivity was 57.5%,and the specificity was 87.7%.4.Under the influence of different gender,age,pathological and other factors,the sensitivity and specificity of the cold-and heat-syndrome by the cold type and heat type lunula were also different.In the elderly,women and squamous cell carcinoma patients,the sensitivity of the identification of cold-syndrome was 96.7% and the specificity was 8.3%.However,in young,male,and adenocarcinoma patients,the sensitivity of identification was 33.3%,and specificity was 98.4%.On the other hand,in women,middle-aged and elderly,and squamous patients,the sensitivity of identification of heat-syndrome of the heat type lunula was 10.0%,and the specificity increased significantly,as high as 98.8%.However,in young,male and adenocarcinoma patients,the sensitivity was 84.6%,and the specificity was 56.3%.Conclusions1.Among NSCLC patients,the cold type is the most common lunula types and successively heat type,normal type and cold-heat complication.And the difference of lunula types is statistically significant in gender,age,pathological pattern.2.The sensitivity of the cold type lunula proof cold-syndrome is higher than the specificity,and the specificity of the heat type lunula proof the heat-syndrome is higher than the sensitivity.So,the lunula can be used as an auxiliary method for dialectical analysis of cold-and heat-syndrome of TCM.It is worthy of further clinical application.