The Study Of Relation Between The EGFR Gene Statement And The Cold Or Heat Syndrome Type In Patients With Stage â…¢B/â…£ NSCLC

ObjectiveBy discussing the relation between EGFR gene statement and the TCM co ldor heat syndrome type in Stage IIIB/IV NSCLC patients, This study may pr ovides a factor of TCM syndrome type for EGFR TKIs therapy of NSCLC, help further study about NSCLC therapy which combine EGFR-TKIs and TCM.MethodsUsing cancer epidemiology research method and gene detection technolo gy, collect TCM syndrome information of patients in stage IIIB/IV NSCLC, a nd identify the TCM cold or heat syndrome type according to the basic the ories of TCM. Use amplification refractory mutation system(ARMS) to detect EGFR gene state of the patients, and divided the patients into wild type group and mutation group according the EGFR gene statement. Relationship between the EGFR gene statement and the TCM cold or heat syndrome type wi11be analyzed.Results1.This study enrolled76patients of stage â…¢B/â…£ NSCLC. Patients with wild-type of EGFR gene was45, including15(33.3%) with cold syndrome and30(66.7%) with heat syndrome; Patients with mutations of EGFR gene was31, including20(64.5%) with cold syndrome and11(35.5%) with heat syndrome. The cold or heat TCM syndromes types of two groups has statistically sign ificant difference (P<0.05).2. Patients with cold syndrome was35, including15(42.9%) males and20(57.1%) females; Patients with cold syndrome was41, including33(80.5%) males and8(19.5%) females. The gender composition of two groups has stat istically significant difference (P<0.01). Patients with cold syndrome in cluded22(62.9%) without smoking history and13(37.1%) with smoking histo ry; Patients with heat syndrome included11(26.8%) without smoking histor y and30(73.2%) with smoking history.With or without smoking history of t wo groups has statistically significant difference (P<0.01).3. Patients with wild-type of EGFR gene including included12(26.7%) w ithout yellow tongue coating and33(73.3%) with yellow tongue coating; Pa tients with mutations of EGFR gene included20(64.5%) without yellow tong ue coating and11(35.5%) with yellow tongue coating. With or without yello w tongue coating of two groups has statistically significant difference (P<0.01). Patients with wild-type of EGFR gene including included26(57.8%) without rapid pulse and19(42.5%) with rapid pulse; Patients with muta tions of EGFR gene included26(83.9%) without rapid pulse and5(16.1%) wi th rapid pulse. With or without rapid pulse of two groups has statisticall y significant difference (P<0.01).Conclusion1. The EGFR gene status and cold and heat TCM syndrome have some relev ance:the patients with wild-type EGFR gene are mainly with TCM syndrome type of cold, the patients with mutation EGFR gene are mainly with TCM sy ndrome type of heat.2The cold and heat TCM syndrome and gender have some relevance:the patients with cold syndrome are mainly females, the patients with heat s yndrome are mainly males. The cold and heat TCM syndrome and smoking hist ory have some relevance:the patients with cold syndrome are mainly witho ut smoking history, the patients with heat syndrome are mainly with smoki ng history.3. The EGFR gene status and tongue coating, pulse have some relevance: the patients with wild-type EGFR gene are mainly with yellow tongue coati ng, the patients with mutation EGFR gene are mainly without yellow tongue coating, the patients with wild-type EGFR gene are mainly with rapid puls e, the patients with mutation EGFR gene are mainly without rapid pulse.