The Value Of Platelet Counts In Short-term Prognosis Of Patients With Stanford Type B In Acute Aortic Dissection

Objective:To retrospective analyze the short-term prognostic value of platelet(PLT)counts at admission in patients with Stanford type B acute aortic dissection.Methods:We consecutively enrolled 81 hospitalized patients of the First Affiliated Hospital of Jinan University,Affiliated Guangzhou Red Cross Hospital of Jinan University of Medicine from January 2010 to December 2017 for the first time confirmed Stanford type B acute aortic dissection(AAD).Patients were divided into death group and survival group according to the end point of hospitalization,and univariate and multivariate Cox regression were performed to determine whether PLT count was an independent risk factor for short-term prognosis of patients with Stanford type B acute aortic dissection,ROC curve was used to study the predictive value of PLT counts in patients with Stanford type B acute aortic dissection and to find the best cutoff value.Kaplan-Meier survival curves were used to compare the in-hospital survival rates of patients with AAD with different levels of PLT counts.Results:Compared with the survival group,the death group PLT counts was significantly lower,there was a significant difference(172.07±57.38×10~9/L VS227.13±75.97×10~9/L),P<0.05;The univariate Cox regression analysis of the factor(P<0.1)into the multivariate Cox regression model analysis,The results showed PLT count(HR:0.993,95%CI:0.987-0.997,P=0.043),The area under the ROC curve of PLT counts was 0.717,the best cut off was 179.5×10~9/L,the sensitivity was 72.5%,the specificity was 63.3%,P=0.001;Log Rang test results showed:There was a statistically significant difference in cumulative survival between the high PLT counts group(>179.5×10~9/L)and the low PLT counts group(<179.5×10~9/L)(P=0.001).Conclusions:Low PLT counts is an independent risk factor of death in patients with Stanford type B AAD in-hospital.