Analysis Of Related Factors Of Impaired Fasting Glucose Or Diabetes Mellitus In Acute Pancreatitis

Objective: To investigate the incidence of impaired fasting blood glucose(IFG)or diabetes mellitus(DM)in patients with acute pancreatitis(AP)in the late,and to analyze the related factors affecting the changes of blood glucose in patients with acute pancreatitis.Methods: This study,taked cases of 788 acute pancreatitis who were not diabetic or had no history of hyperglycemia as research objects,also collected the general data and clinical data of the patients mentioned above.The general data included gender,age,height,weight,history of drinking,frequency of disease.The clinical data included the testing index of white blood cell count,C-reactive protein(CRP),triglyceride(TG),cholesterol(TC),serum calcium,maximum blood glucose concentration and CT images within 48 hours after admission.The above mentioned patients were followed up for 6months after discharge for there index of fasting blood glucose.According to the follow-up fasting glucose index,the results of late blood glucose in patients with acute pancreatitis were divided into normal fasting plasma glucose(NFG),impaired fasting glucose(IFG),and diabetes(DM).The data collected in this study were grouped according to various relevant criteria.Follow-up results were normal pancreatitis patients with fasting blood glucose as the control group.This article compares the incidence of IFG and DM in different groups of patients with acute pancreatitis and uses univariate analysis and Logistic multivariate regression analysis methods to analyze the many factors that affect the different blood glucose results in patients with acute pancreatitis.Results:(1)In univariate analysis,gender and alcohol history had no effect on blood glucose of acute pancreatitis in the later stage(P>0.05).While age,body mass index(BMI),frequency of disease,severity of disease,leukocyte count,C-reactive protein,triglyceride,cholesterol,blood calcium,maximum blood glucose concentration within 48 hours of admission,as well as CT gradings,all affected the results of blood glucose with acute pancreatitis(P < 0.05).(2)Logistic regression analysis further revealed that in moderately severe acute pancreatitis(MSAP),severe acute pancreatitis(SAP),CTSI was greater than or equal to 7,triglyceride concentration was greater than 2.3mmol/L,serum calcium concentration was less than 2mmol/L,the highest blood glucose concentration after admission within 48 hours was more than 11.1mmol/L,which were risk factors for impaired fasting glucose in patients with acute pancreatitis.The odds ratio(OR)was in9.141,9.725,7.107,2.730,2.904,9.010.It were great risk factors for diabetes mellitus in patients with acute pancreatitis,with the BMI larger than or equal to 24kg/m2,CTSI more than 7 points,serum calcium concentration less than 2mmol/L,the highest blood glucose concentration larger than11.1mmol/L after admission within 48 hours.The odds ratio(OR)was in12.502,17.0 70,46.313,7.645,80.582.Conclusions: CTSI greater than or equal to 7,triglyceride concentration greater than2.3mmol/L,serum calcium concentration less than 2mmol/L,the highest blood glucose concentration after admission within 48 hours more than 11.1mmol/L,were risk factors for impaired fasting glucose in patients with acute pancreatitis.It were also great risk factors for diabetes mellitus in patients with acute pancreatitis,with the BMI larger than or equal to 24kg/m2,CTSI more than 7 points,serum calcium concentration less than2mmol/L,the highest blood glucose concentration larger than 11.1mmol/L after admission within 48 hours.Therefore,the patients with acute pancreatitis existing with risk factors mentioned above should strengthen their blood glucose monitoring,detect and diagnose early,and make a early treatment of secondary acute pancreatitis diabetes to avoid the occurrence of related complications.