| Objective: The purpose of this study was to use a clinical randomized controlled study to evaluate whether patients with decreased ovarian reserve were treated with Zuogui Pill in combination with Femoston or with Femoston alone.Before and after treatment,the scores of TCM symptoms,efficacy,and serum sex hormone levels were compared.Ovarian arterial blood flow changes provide a certain reference and basis for clinical promotion and application.Methods: Sixty female patients who met the gynecological clinic of Shouguang City Maternal and Child Health Hospital from December 2016 to May 2017 and met the diagnostic criteria of decline in ovarian reserve were selected.According to the order of enrollment,60 patients with decreased ovarian reserve were divided into treatment group and control group with 30 patients in each group.The control group was treated with fennetone,and the treatment group was treated with Zuogui Pills combined with fenoxetone for 1 course of treatment.The changes of TCM symptom scores before and after treatment and the total curative effect were observed and recorded.The observations were taken at 2 days of the menstrual cycle.Serum levels of follicle stimulating hormone(FSH),basic luteinizing hormone(LH),estradiol(E2),FSH/LH levels were measured,and ovaries were measured by vaginal color Doppler ultrasound.Volume(Ovarian Volume,OV),Ovarian antral follicle count(AFC),Ovarian maximum mean diameter(MOD),Pulsatility index(PI)Peak systolic velocity of uterine artery(Pea k systolic velocity,PSV),the resistance index(RI)value.Results:(1)Changes of TCM symptom scores in patients with decreased ovarian reserve due to Zuogui Pill combined with Femoston: Intra-group comparison,menstrual cycle,color quality,menstrual flow,lumbar ache,dizziness,tinnitus,insomnia after treatment The scores for dreams,hot flashes,sweating,irritability,palpitations,and fatigue were all decreased,and were significantly lower than before treatment.The differences were statistically significant(P<0.05),and the patients in the treatment and control groups were The total score after treatment(10.81±5.24,15.38±5.05)was also lower than before treatment(22.58±8.32,22.51±8.56).Comparison of the two groups of patients,the treatment of the treatment group after the symptoms and total scores of the Chinese medicine were significantly lower than the control group,the difference was statistically significant(P<0.05).(2)The efficacy of Zuogui Pill combined with Femoston in the treatment of decline in ovarian reserve function: In the treatment group,10 cases were cured,7 cases were markedly effective,7 cases were effective,and 6 cases were ineffective;5 cases of the control group recovered after treatment and were significantly effective In 4 cases,6 cases were effective,and 14 cases were ineffective.After comparison,the total effective rate(80.0%)in the treatment group was significantly higher than that in the control group(53.33%),and the difference was statistically significant(P<0.05).(3)Effect of Zuogui Pill Combined with Femoston on sex hormones in patients with decreased ovarian reserve: In the treatment group and the control group,the FSH,LH,FSH/LH,and E2 values decreased after treatment.Significantly lower than before treatment,the differences were statistically significant(P<0.05).After treatment between the two groups,the values of FSH,LH,FSH/LH,and E2 in the treatment group were significantly lower than those in the control group,and the differen ces were statistically significant(P<0.05).(4)Effect of Zuogui Pill Combined with Femoston on the parameters of ovarian artery blood flow in patients with decreased ovarian reserve: Compared with the two groups of patients in the treatment group and the control group,the PSV value was improved after treatment and was significantly higher than before treatment.After treatment,PI and RI values were all decreased,and significantly lower than before treatment,the differences were statistically significant(P<0.05).After treatment,the PSV values of the treatment group were significantly higher than those of the control group after treatment.The PI and RI values were significantly lower than the control group,and the differences were statistically significant(P<0.05).(5)Effect of Zuogui Pill Combined with Fentongtong on AFC,OC and MOD in Patients with Decreased Ovarian Reserve Function: In the treatment group and control group,the AFC,OV and MOD values increased after treatment.(6)And significantly lower than before treatment,the difference was statistically significant(P<0.05).After treatment,the AFC,OV,and MOD values of the treatment group were significantly better than those of the control group.The differences were statistically significant(P<0.05).Conclusion:(1)Zuogui Pill combined with Femoston can significantly improve the symptoms of various TCM patients with DOR,and the curative effect is significantly higher than that of simple application Femoston.(2)Zuogui Pills combined with Femoston in the treatment of patients with DOR reduce FSH,LH,FSH / LH values,E2,to achieve the yin and yang reconcile,which is conducive to adjust the level of female endocrine and promote the recovery of ovarian function,the effect is better than simple application of Femoston.(3)Zuogui Pill combined with Femoston can significantly increase the perfusion of ovarian arteries,reduce their vascular resistance,and improve pelvic microcirculation,which is more conducive to the recovery of ovarian function.The effect is better than simply applying Femoston.(4)Zuogui Pill combined with Femoston can significantly increase the value of AFC,OV and MOD compared with the use of Femoston alone.It has a very important positive effect on improving the ovarian reserve function.Is the effect better than that of Femoston. |
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