A Case Report Of Renal Damage Of Antineutrophil Cytoplasmic Antibody Associated Systemic Vasculitis And Review Of The Literature

Objective: Antineutrophil cytoplasmic antibody associated systemic vascufitis(AASV)is an autoimmune disease.With the understanding of its epidemiological studies,it has been found that the incidence rate is gradually higher than before.The clinical manifestations of the disease are diverse,often involving multiple systems,with the most common kidney and lung involvement.However,it lacks specific symptoms,resulting in a high rate of missed diagnosis and misdiagnosis.The treatment intervention is not timely and the prognosis is poor.Through the review of case reports and related literature,we should fully understand its early clinical manifestations and laboratory abnormalities,make clear diagnosis and formulate effective treatment plan,so as to provide clinical guidance for the diagnosis and treatment of this disease in the future.Method: Taking a case of AASV renal impairment with intermittent fever and double-limb edema as the main first symptom in our department,we summarized the characteristics of the case and reported the progress of the disease,the course of diagnosis and treatment,relevant examinations,and pathological findings.At the same time,by reviewing the relevant literature,the understanding of the mechanism,clinical features and treatment plan of the disease can be improved,misdiagnosis and missed diagnosis rate can be reduced,and early intervention can be sought to improve the patient’s prognosis.Results: The patient was male,51 years old.He was diagnosed in our hospital due to "intermittent fever for more than 40 days and double-limb edema for 3 days." We combined the clinical manifestations,auxiliary examinations,and renal biopsy to confirm the pathological manifestations of vasculitis and renal damage.After treatment with glucocorticoid combinedwith cyclophosphamide and anti-infection,the symptoms improved,and the serum serological ANCA decreased compared with before.Without further progress,the condition was relieved and discharged.Conclution: The early diagnosis and treatment of AASV are very important.If the diagnosis and intervention are not timely,the mortality rate is high.When the condition affects the kidneys,it usually manifests as neo-immune necrotic crescentic glomerulonephritis.This type of progress is rapid and the prognosis is poor.When microscopic hematuria,edema,and other systemic and multiple-system involvements occur,we should think of a diagnosis of AASV,perform serological ANCA and renal biopsy in time,make a diagnosis,and develop a treatment plan.