The Clinical And Imaging Features Of Patients In Acute Cerebral Infarction Combined With Nephrotic Syndrome

Objective: To explore the clinical and imaging features of acute ischemic stroke combined with nephrotic syndrome,and analyze the underlying pathogenesis.Method: We recruited 51 patients diagnosed with acute ischemia stoke combined with nephrotic syndrome.The 49 controls,who were matched to the cases by the general data and diagnosed with acute ischemia stoke,were enrolled from the hospitalized patients at the same time.Clinical,laboratory and imaging data were reviewed retrospectively.Results:1.There were no statistically significant differences between the two groups in the general data.2.Compared with the control group,the serum level of CHO,TG,LDL,and FIB in the case group were significantly higher,and the ATⅢ was significantly lower.3.Comparing the degree of vascular stenosis,the case group had statistically significantly higher cerebral artery stenosis scores.4.Comparing the two groups,there were no statistically significant differ-ences in the National Institutes of Health Stroke Scale(NHISS)scores at admission.5.There were no correlations between the serum albumin,24-hour urine protein,the blood lipid levels,and the duration of nephrotic syndrome with the degree of the vascular stenosis in the case group.6.Only 13 patients(25.5%)in the case group were treated with low molecular weight heparin anticoagulation.Conclusions:1.The patients with acute ischemic stroke combined with nephroticsyndrome had severe lipid metabolism disorder and hypercoagulability.2.The patients with acute ischemic stroke combined with nephrotic syndrome showed more severe vascular stenosis and the MRI showed multiple intracranial lesions.