Oxycodone Hydrochloride And Flurbiprofen Axetil For Postoperative Headache After Thyroid Surgery

Objective:To compare the efficacy of oxycodone hydrochloride and flurbiprofen axetil on the prevention of postoperative headache after thyroid surgery.Methods :In this study,150 patients undergoing thyroid surgerywere randomly divided into control group(group C)、oxycodone hydrochloride group(group O)andflurbiprofen axetil group(group F),50 cases in each group.After entering the operation room,the patients were routinely monitored for noninvasive blood pressure(measured every3-5min),electrocardiogram,blood oxygen saturation,BIS,and venous access was established.The induction of anesthesia and drug administration order: Propofol 2mg/kg,sufentanil 0.5ug/kg,cisatracurium besilate 0.2mg/kg.After the induction of anesthesia,tracheal intubation was performed.Male ID7.5 catheter and female ID7.0 catheter were used and / or no recurrent laryngeal nerve monitoring catheter was used according to the operative requirements.Sevoflurane 1.5%-2%、 propofol 4-6mg/(kg·h)and remifentanil0.1-0.5ug/(kg · min)were used in the maintenance of anesthesia to make the carbon dioxide maintain at 35~45mm Hg and intraoperative BIS 40~60.Physiological saline(10ml)、oxycodone hydrochloride(0.1mg/kg)or flurbiprofen axetil(1.5mg/kg)was administered intravenously for each group 30 minutes before the end of the surgery.At the end of operation,tropisetron 5 mg was used in all the three groups.After operation,all patients were transferred to the postanesthesia care unit(PACU).When the patient had the extubation indication,the tracheal catheter was removed in the PACU.We observed the duration of surgery,recovery time,incidence and the visual analogue scale(VAS)at the time of 24 h and 48 h after extubation and the untoward effect such as nausea,vomitting,dizzy in eachgroup.Results:12 patients There was no significant difference in age,weight,sex in three groups(P>0.05).Otherwise,there was no significant difference in operative time between the 3 groups(P > 0.05).In the aspect of the time of awakening,group O was significant longer than group C and group F(P<0.05),but there was nosignificant difference between group F and group C(P>0.05).There was no significant difference in untoward effect in the three groups(P > 0.05).The incidence of headache at 24 hours and 48 hours after extubation: there was a significant difference between group O and group C and group O compared with group F(P < 0.05),while the incidence of headache in group F decreased compared with group C,but the difference was not statistically significant(P >0.05).The VAS score of headache at 24 hours and 48 hours after extubation: there was a significant difference between group O and group C 、group O and group F(P < 0.01),but there was no significant difference between group F and group C(P > 0.05).Conclusions : The Oxycodone hydrochloride has significant effect for prevention of headache after thyroid surgery,but the recovery time was prolonged.However,the preventive effect of flurbiprofen axetil is not obvious.