Clinical Study On The Relationship Between Monocyte Count/HDL-C Concentration Ratio And The Severity Of Coronary Artery Lesions In Acute Coronary Syndrome

Objective: To improve the accuracy of judging the severity of coronary artery lesions in acute coronary syndrome and understand the changes of monocyte count/HDL-C concentration ratio and other indicators in acute coronary syndrome of varied severity.Methods: A retrospective analysis of the clinical data of 212 patients with chest pain were admitted by the Department of Cardiology of Second Hospital Affiliated to Nanhua University in January 2015-2017 year in January and undergoing a coronary angiography.Among them,110 were male and 102 were female,who aged from 40.2 to 71.3 years old and the average age is 60.5 years.All patients’ laboratory data,sex,age,smoking history,drinking history,family history and other detailed case data were analyzed.Patients with pulmonary infection,long-term use of immunosuppressive agents,malignant tumor,nosohemia and other patients were excluded.According to the clinical manifestations and the results of coronary angiography,all patients were divided into 150 cases of the acute coronary syndrome(ACS)group and 62 cases of the healthy control group.coronary artery stenosis degree is less than or equal to 50% as the healthy control group,a total of 62 cases,the stenosis degree of over 50% for a total of 150 cases of coronary heart disease group.The ACS group was then divided into the acute myocardial infarction(AMI)group and the unstable angina(UA)group according to clinical data such as myocardial biomarkers,62 cases of the AMI group and 88 cases of the UA group.When the patients were admitted to the hospital,including blood routine tests,high-density lipoproteins,triglycerides,C-reactive protein,and myocardial biomarkers were taken before completion of coronary angiography,and monocyte count/ high-density lipoprotein concentration ratio are obtained based on the results from above.The data obtained were analyzed by the use of SPSS20.0 data analysis system for comparative analysis.Results: 1.Compared with the healthy control group,the ACS group and the healthy control group,AMI group and UA group respectively,with age,gender,hypertension,drinking history,history of diabetes,family history of coronary heart disease were compared,the data showed no statistically significant difference(P > 0.05).The difference in smoking was statistically significant(P<0.05)between the control group and the ACS group.There was a statistically significant difference in smoking between the AMI group and the UA group compared with the control group(P<0.05).2.There was no statistically significant difference(P >0.05)in the data of leucocyte,lymphocytes,red blood cells,and creatinine among the control group,the UA group,and the AMI group.The levels of mononuclear cells,triglycerides,total cholesterol,and CRP in the control group were significantly lower than those in the UA and AMI groups,with significant differences(p<0.05).The high density lipoprotein(HDL)in group UA and group ACS was lower than that of the control group(P < 0.05).There was no significant difference in total cholesterol and CRP between the UA group and the AMI group(p>0.05).There was significant difference in triglyceride,high-density lipoprotein and monocyte count between UA group and AMI group(P < 0.05).3.The ratio of monocyte count/high-density lipoprotein concentration and Gensini scores in the UA and the AMI groups were significantly different from those in the control group.The ratios of Monocyte count/high-density lipoprotein concentration and Gensini scores in the AMI group were higher than those in the UA group and the control group.The monocyte count/high density lipoprotein concentration and Gensini scores in the UA group were significantly higher than those in the control group,with significant differences(p<0.05).4.In the ACS group,monocyte count and monocyte count/high-density lipoprotein concentration were positively correlated with the Gensini score,and the increase in Gensini score was accompanied by an increase in monocyte count and monocyte count/high-density lipoprotein concentration ratio(r=0.26,p<0.001,r=0.33,p<0.001).High-density lipoprotein levels were negatively correlated with Gensini scores,and high-density lipoproteins decreased with increasing Gensini score(r =-0.31,p < 0.001).Conclusion: The ratio of monocyte and high density lipoprotein cholesterol concentration was positively correlated with coronary heart disease Gensini score.To some extent,monocyte count,high-density lipoprotein cholesterol concentration,and the ratio of monocyte count to high-density lipoprotein cholesterol concentration can assess the severity of coronary lesions in acute coronary syndromes.