| Objectives: To investigate the influence of the pancreatic alpha cell function in different lipid status through analyzing the correlation analysis of plasma glucose,insulin,glucagon,insulin area under curve and glucagon area under curve.Methods: The study included 1016 patients diagnosed with type 2 diabetes in the endocrinology department of the General Hospital of Shenyang Military Region.The selected patients with fasting state proceeded to Oral Glucose Tolerance Test,collect patients’ fasting blood glucose,glucagon,lipids,glycosylated hemoglobin(HbA1c)levels and 30 minutes,60 minutes,120 minutes,180 minutes blood glucose,glucagon levels after glucose loading.In addition to calculate the 0-180 minutes glucagon area under curve(AUC-Glu)and insulin area under curve(AUC-Ins),finally calculate the glucagon area under curve /insulin area under curve(AUC-Glu/Ins).On the basis of triglyceride(TG),cholesterol(TC),low density lipoprotein(LDL),high-density lipoprotein(HDL)group,respectively for age,BMI,HbA1 c,as well as fasting blood glucose,glucagon,lipids levels and 30 minutes,60 minutes,120 minutes,180 minutes blood glucose,glucagon levels after glucose loading and AUC-Glu,AUC-Ins and AUC-Glu/Ins is analyzed.Results: The blood glucose and HbA1 c of dyslipidemia group were higher than those of the non-dyslipidemia group(P <0.05).Dyslipidemia group’ fasting blood glucose,glucagon levels and 30 minutes,60 minutes,120 minutes,180 minutes blood glucose,glucagon levels after glucose loading and AUC-Glu were higher than those of the nondyslipidemia group(P <0.05).The glucose of TC abnormal group in fasting and 30 minutes,60 minutes,120 minutes,180 minutes after glucose loading and HbA1 c were significantly higher than those in the non-TC abnormal group(P<0.05).In addition,The glucagon of TC abnormal group in fasting and 30 minutes,60 minutes,120 minutes,180 minutes after glucose loading and AUC-Glu were significantly higher than those in the non-TC abnormal group(P<0.05).The glucose of LDL abnormal group in 180 minutes after glucose loading and HbA1 c were significantly higher than those in the non-LDL abnormal group(P<0.05).The glucose of TG abnormal group in fasting and 30 minutes,60 minutes,120 minutes,180 minutes after glucose loading and Hb A1 c were significantly higher than those in the non-TG abnormal group(P<0.05).In addition,The glucagon of TG abnormal group in fasting and 30 minutes,60 minutes,120 minutes,180 minutes after glucose loading and AUC-Glu were significantly higher than those in the non-TG abnormal group(P<0.05).The glucagon of HDL abnormal group in fasting and 30 minutes,60 minutes,120 minutes,180 minutes after glucose loading were lower than those in the non-HDL abnormal group,But there was not statistically significance(P > 0.05).The TC abnormal group was divided into two groups according to the median.The glucose of TC abnormal high group in fasting and 30 minutes,60 minutes,120 minutes,180 minutes after glucose loading were significantly higher than those in the non-TC abnormal group(P<0.05).The glucagon of TC abnormal high group in fasting and 30 minutes,60 minutes,120 minutes,180 minutes after glucose loading were significantly higher than those in the non-TC abnormal group(P<0.05).AUC – Glu and AUC-Glu/Ins of TC abnormal high group was significantly higher than those in the non-TC abnormal group(P<0.05).The TG abnormal group was divided into two groups according to the median.The glucose of TG abnormal high group in fasting and 30 minutes,60 minutes,120 minutes,180 minutes after glucose loading and HbA1 c were significantly higher than those in the non-TG abnormal group(P<0.05).The glucagon of TG abnormal high group in fasting and 30 minutes,60 minutes,120 minutes,180 minutes after glucose loading were significantly higher than those in the non-TG abnormal group(P<0.05).We put insulin,glucagon and blood lipids into multi-factor Logistic regression analysis.It can be found that after adjusted for age,BMI,glycosylated hemoglobin,in the multi-factor regression analysis of TG abnormal group,glucagon(OR: 1.003(95% CI,1.001 1.005)] is an independent predictor of TG abnormality,P < 0.001,meaning that glucagon elevated by one unit,the risk of abnormal TG increased 0.3%.Insulin [OR: 1.006(95%CI,0.977-1.014)] was not an independent predictor of TG abnormality,P>0.05.In the multi-factor regression analysis of TC abnormal group,glucagon(OR: 1.004(95% CI,1.002 1.006)] is an independent predictor of TC is abnormal,P < 0.001,meaning that glucagon elevated by one unit,the risk of abnormal TC increased 0.4%.Insulin [OR: 1.007(95%CI,0.977-1.018)] is was an independent predictor of TG abnormality,P>0.05.Conclusions: Blood glucose and glucagon levels in type 2 diabetes patients with dyslipidemia were higher than those with normal blood lipids.The type 2 diabetes patients with abnormal TG and/or TC have higher blood glucose and glucagon level than those patients with normal TG and/or TC.And higher abnormal TG and/or TC may be more importance to glucagon level when TG and/or TC is abnormal.For type 2 diabetes mellitus patients with dyslipidemia,the more amounts of dyslipidemia components,the higher blood glucose level and the higher the ratio of glucagon to insulin.In patients with type 2 diabetes,glucagon is an independent risk factor for TC and TG abnormalities. |
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