Relationship Between Ulcerative Colitis And Coagulation Function

Background:Ulcerative colitis（UC）is an abnormal immune-mediated chronic inflammation of the intestine caused by multiple causes.It mainly affects the colorectal mucosa and submucosa.The common clinical manifestations are abdominal pain,diarrhea,mucus,pus,and blood.Its etiology is not yet clear,and a number of studies have shown that it may be related to genetic factors,immune factors,and environmental factors.Many recent studies have shown that the incidence of ulcerative colitis in Asia is increasing year by year.The reason for this is not yet clear.It may be related to changes in people’s lifestyles,health awareness,medical care,and living standards.Although the incidence of UC in China is on the rise,there is relatively little research on UC,and the etiology,clinical manifestations,and treatment of UC in China may differ greatly from those in the West.These aspects require further research.Many scholars have found that patients with active ulcerative colitis have high blood viscosity and may even have thrombosis.Studies have shown that the hypercoagulable state of the blood can lead to the formation of intestinal microthrombi in UC patients^[1].The pathogenesis of UC may involve the involvement of intestinal microthrombosis,so the hypercoagulable state of UC patients is of increasing concern.At present,the UC diagnosis lacks the gold standard,and is mainly analyzed through clinical symptoms,endoscopic findings,and histopathological examination of the intestinal mucosa.Colonoscopy can intuitively understand the intestinal mucosal lesions,and can be biopsy biopsy.At present,this diagnosis of UC is widely used,but due to its high cost,poor patient compliance,clinical applications are affected,and it is impossible to accurately and timely assess the condition of UC patients.Follow-up and review of UC patients are limited due to poor compliance and tolerability of colonoscopy,especially in patients with severe ulcerative colitis,may also increase the corresponding complications.Therefore,the rapid and effective assessment of the severity of UC patients has important clinical significance for the diagnosis and treatment of UC.Purpose:To analyze the change of coagulation index in active ulcerative colitis and its relationship with the severity of the disease,and to explore the correlation between the changes of each index.Provide a valuable reference for clinical assessment of illness and treatment guidance.Materials and Methods:From August 2015 to July 2017,96 patients with active ulcerative colitis who were hospitalized at Qingdao Municipal Hospital were selected as the case group.Their clinical data were complete and the diagnosis was clear.All patients completed colonoscopy,which met the diagnostic criteria of the 2012 Guangzhou Conference of the Chinese Medical Association’s Digestive Disease Branch^[2],and the modified Mayo index score was>2 points.It was also based on the improved version of the Truelove and Witts inflammation criteria^[3],the case composition was mild,moderate,severe 3groups.Another 100 Qingdao Municipal Hospital health checkers were selected as the control group.Prothrombin time（PT）,activated partial thromboplastin time（APTT）,D-dimer（DD）,and platelet count（PLT）were analyzed in case group and control group to compare PT,APTT,DD,PLT Differences between different severity levels in active UC.Results:1.The PT,APTT,and PLT in the case group were significantly higher than those in the control group,and the difference was statistically significant（P<0.05）.The D-D difference was not significant（P>0.05）.There were significant differences in PT,APTT,D-D and PLT between the mild group,the moderate group,the severe group and the control group（P<0.05）.2.The PT,D-D and PLT in the mild group were lower than those in the moderate and severe groups,and the difference was statistically significant（P<0.05）.The PT and D-D in the severe group were higher than the moderate group,and the difference was significant.Statistical significance（P<0.05）;There was significant difference in PT,D-D and PLT between the three groups（P<0.05）.3.Using Pearson to analyze the correlation between UC clotting markers:The results showed that PT and APTT were positively correlated（r=0.440,P<0.05）,and PT and D-D were positively correlated（r=0.340,P<0.05）.Conclusion:1.PT,APTT,D-D,PLT can be used as predictors for judging the severity of active UC.2.Active ulcerative colitis significantly increased PT,and there is a synergistic relationship with APTT and D-D,may jointly promote the occurrence and development of the disease,aggravate the condition.