To Evaluate The Impact Of Clinical Factors On Pregnancy Outcome Of Ovulation Induction In Women With Polycystic Ovary Syndrome

Objective To evaluate the impact of clinical factors on pregnancy outcome of ovulation induction in women with polycystic ovary syndrome(PCOS),and to explore the appropriate cycles and the ways of the treatments in ovulation induction.Methods A total of 165 PCOS patients were selected from November 2014 to October 2015 in Dalian Maternal and Child Health Care Hospital.A total of 529cycles were ovulated.All patients were divided into pregnancy group or non-pregnancy group according to their pregnancy outcome.The clinical indexes and therapeutic methods were compared between the two groups.All the data were input into the computer database,and the data were analyzed by SPSS 17.0 statistical software.X~2test was used to compare the rate between groups.The significant level of the analysis was P<0.05,which indicated that the difference was significant.Results(1)The pregnancy rate with the timed intercourse was high(21.18%)in the third stimulation cycle and begin to decline in the eighth cycle,but there was no significantly difference between the groups(P>0.05).(2)The upward trend was shown in intrauterine insemination compared with the timed intercourse(P>0.05),but there was no significantly difference.(3)The clinical pregnancy rate(54.5%)in the group of age≤30 years old is increased significantly than that(21.4%)in the age group of 36to 40 years(P=0.024).(4)The pregnancy rate between PCOS with hyperandrogenemia and non-hyperandrogenemia hadn’t shown significantly difference(54.6%vs38.5%)(p=0.05).(5)PCOS patients with LH/FSH ratio in the range of 1 to 2,the pregnancy rate was highest at 62.3%,compared with the other two groups of LH/FSH<1 at42.4%and LH/FSH≥2 at 30.4%(p=0.02 and p=0.015 respectively).(6)The pregnancy rate among the three groups of follicle number in<12,12-20、≥20 hadn’t shown significantly difference(P>0.05).(7)The clinical pregnancy rate(50%vs 49%)between ovulation and non-ovulation group in natural cycle hadn’t shown significantly difference(P=0.958).(8)According to NIHl990 criteria,the pregnancy rate of type A in PCOS was higher than that of type D(56.1%vs 38.6%)(P=0.035).Conclusions(1)The clinical pregnancy rate was shown downward trend in the eighth cycle in PCOS patients,and seven cycles could be the appropriate numbers of stimulation cycle,but there was no significantly difference in statistics.The sample size could be expanded further.(2)From the fifth cycle of ovulation induction,the upward trend was shown in intrauterine insemination compared with the timed intercourse.although there was no significantly difference between groups.To increase the number of treatment cycles may provide more credible evidence.(3)Age was still the absolute factor affecting clinical pregnancy rate in PCOS patients.The clinical pregnancy rate of patients over 35 years old is significantly lower than that of patients under 35 years old.(4)PCOS patients with LH/FSH ratio between 1-2 were more likely to conceive after ovulation induction.(5)The initial state of PCOS Patients,such as the severity of Hyperandrogenemia and PCO in ultrasonic,and whether or not ovulation in natural cycle,didn’t influence the outcome of treatment.(6)According to NIHl990 criteria,the pregnancy rate in type A of patients with PCOS had a better outcome.