TCM Syndrome Of Aids And The Level Of T-lymphocyte Subgroup And IL-2 And IL-4 Relationgs

Objective:To investigate the distribution of TCM syndromes in patients with AIDS and the level of t-cell subpopulation and IL-2,IL-4 relationship.Methods:154 cases of AIDS patients who had not been treated with antiretroviral therapy and 6 to 12 months of antiviral therapy were collected from the Fourth People’s Hospital of Nanning.According to the analysis of TCM syndromes,AIDS patients were divided into three groups:30 cases of empirical group,50 cases of deficiency syndrome group and 74 cases of deficiency and deficiency syndrome.According to whether the antiviral treatment is divided into two groups:no antiviral treatment group of 93 cases,the antiviral group of 61 cases.The levels of CD4+T and CD8+T cells in all AIDS patients were detected by flow cytometry.The levels of IL-2 and IL-4 in serum of all AIDS patients were detected by enzyme-linked immunosorbent assay(ELISA).Result:1.AIDS patients with TCM syndromes frequency from high to low order are:the actual situation of syndrome,deficiency,empirical.(37.66%),spleen(37.66%),heart(10.39%),stomach(3.90%),and the stomach(3.90%),Large intestine(1.30%).2.The number of CD4+T cells in HIV/AIDS patients with different TCM syndromes were 361.57±169.24/mm~3,297.74±204.86/mm~3,155.73±148.89/mm~3,and the differences among the groups were Was statistically significant(F=12.728,P<0.05).The number of CD8+T cells was 810.69±354.08/mm~3,891.32±593.42/mm~3,655.77±494.18/mm~3,the difference was statistically significant(F=3.358,P=0.037).Serum IL-2 levels were 6.48±1.50pg/mL,6.01±2.16pg/mL,5.42±1.74 pg/mL,respectively.CD4+T/CD8+T were 0.48±0.21,0.37±0.25,0.27±0.29,the difference was statistically significant(F=6.592,P=0.002).Serum IL-4 levels were 3.22±1.24 pg/mL,3.86±2.20 pg/mL,3.11±1.95 pg/mL,respectively.(F=3.929,P=0.022).There was no significant difference in IL-4 level between the two groups(F=0.756,P=0.451).There was no significant difference between the two groups(P>0.05).3.The correlation between excess syndrome group and T lymphocyte subsets,CD4/CD8,IL-2 and IL-4 in AIDS patients was statistically significant(χ~2=14.081,P=0.000<0.05).The coincidence rate of the model was78.3%.The positive correlation with CD4+CD8,IL-2 and IL-4 was CD4+Cell count,other indicators no correlation.The correlation between the deficiency syndrome group and the T lymph subgroup,CD4/CD8,IL-2 and IL-4 was statistically significant(χ~2=6.301,P=0.012<0.05).The coincidence rate of the model was 64.3%,and the immunological index was negatively correlated with the deficiency CD4+cell count,other indicators no correlation.The correlation between the syndrome of intermingled deficiency and excess group and the T lymph subgroup,CD4/CD8,IL-2 and IL-4 was statistically significant(χ~2=18.734,P=0.000<0.05).The coincidence rate of the model was 64.3%,and the immunological index was negatively correlated with the deficiency CD4+cell count,other indicators no correlation.4.Twenty patients,26 patients,47 patients with antiviral group,25 patients and 26 patients without antiviral group and antiviral group TCM syndromes are based on the actual situation.The distribution of syndromes was not statistically different(P>0.05).Conclusion:(1)The TCM syndromes of HIV/AIDS patients in AIDS may be mainly based on the syndrome of intermingled deficiency and excess,followed by deficiency and excess syndrome.(2)The immune function of the syndrome of intermingled deficiency and excess is worse than the excess and deficiencysyndrome,the condition is more serious.(3)There was a positive correlation between excess syndrome and CD4+cell count.There was a negative correlation between deficiency syndrome and CD4+cell count,and there was a negative correlation between excess and deficiency mingled syndrome and CD4+cell count.Three kinds Syndrome and CD8+T cell counts,IL-2,IL-4 levels were not correlated.CD4+cell count may can be used as one of the objective basis of TCM syndrome differentiation.(4)AIDS patients may exist from the excess syndrome-deficiency syndrome-excess and deficiency mingled syndrome.(5)Antiviral therapy within 12 months of treatment may not affect the distribution of TCM syndromes.