Analysis And Clinical Significance Of Blood Tumor Makers In 112 Patients With Cirrhosis And Liver Cancer

[Objective]The liver is the largest digestive gland in the human body,the liver has the secretion of bile,consuming and defense,synthesis of clotting factors and albumin,the three major nutrients metabolism,regulation of blood volume and water and electrolyte balance and other functions(satellite edition version 8 physiology).Liver disease has become a health hazard of a important disease categories,there are a lot of cause of liver damage,including virus infection,alcohol injury,metabolic abnormalities,autoimmune injury,drug damage,such as lack of blood stasis hemorrhagic lesions(satellite version 8 edition of internal medicine).In liver disease,the liver function can be damaged in different degrees.In clinic,the Child-pugh score is commonly used to indicate the liver’s reserve function.(15 practical internal medicine)in recent years,along with the deepening study,serum tumor markers,such as carbohydrate antigens is not only the rise of different levels in primary liver cancer[1-2],as well as in patients with liver cirrhosis and other liver diseases have varying degrees of increase[3].The purpose of this study was to explore the relationship between the four types of tumor markers cea,ca125,ca19-9,AFP,liver cirrhosis,liver cancer patient child-pugh score and liver injury.[Methods]1.All the 112 subjects to be observed were used in the manner of regular fasting blood sampling.2.By shandong provincial hospital laboratory automatic electrochemical luminescence immunity analyzer,the method of operation,in strict accordance with the instructions in the detection of serum cea,ca125,ca19-9,AFP level four tumor markers.Normal reference value,ca1250-40u/ml,cal9-9 0-30u/ml,afp0-7ng/ml,cea0-6ng/ml,TBAO-10umol/ml,alp50-130u/ml,ast29-40u/ml.3.The results were indicated by mean and/or standard deviation,and the data was analyzed using SPSS statistical software.[Results]1.Comparison of cea,ca125,cal9-9 and AFP levels in different child-pugh stages of patients with cirrhosis..The liver function of patients with liver cirrhosis Child-pugh,class A,B,C,blood ca125 levels:C(401.5 ± 210.1 U/ml),higher than that of class B(202.3±140.6 U/ml),B(202.3 ± 140.6 U/ml)higher than that of A grade(59.7 ± 30.9 U/ml),statistically significant difference(p<0.05).Serum AFP level:level C(96.3± 30.2ng/ml),higher than grade B(60.3±24ng/ml),B(60.3±24.9ng/ml)was higher than grade A(20.25,plus or minus 10.7ng/ml),and the difference was statistically significant(p<0.05).Blood CEA level:level A(7.39 ± 1.51U/ml),class B(7.62± 1.75u/ml),grade C(7.56± 1.43U/ml),no significant difference.Blood cal9-9 level:level C(86.2 ± 20U/ml)was higher than grade B(71.9± 26U/ml),and B(71.9 ± 26U/ml)was higher than grade A(53.7 ± 14U/ml),and the difference was statistically significant(p<0.05).2.The blood cea,cal25,ca19-9 and AFP levels of patients with cirrhosis were compared with those in the TBA normal group.The TBA elevated group cal25+(256.13±150.7U/ml)was higher than the normal group of TBA(171.1 ± 79.7U/ml),and the difference was statistically significant(p<0.05).Serum AFP level:TBA normal group(51.27±19.9ng/ml),TBA elevation group(47.6 ±14.3ng/ml),the difference was not statistically significant(p BBB 0 0.05).Blood CEA level:TBA normal group(6.56 ± 1.13U/ml),TBA elevation group(5.32 ±0.75U/ml),the difference was not statistically significant(p>0.05).Serum cal9-9 level:TBA normal group(56.9± 19.3U/ml),TBA elevation group(59.1± 17.3U/ml),the difference was not statistically significant.3.Blood cea,ca125,ca19-9 and AFP levels in patients with cirrhosis were compared with ascites and ascites.Ca125(321.5 ±126.32U/m)was higher than that in the ascites group(79± 23.32U/m),and the difference was statistically significant(p<0.05).Serum AFP level:ascites(63.21 ± 21.1ng/ml),no ascites group(67.45± 30.18ng/ml),the difference was not statistically significant(p>0.05).Blood CEA level:ascites group(9.98 ±2.16U/ml),no ascites group(10.32± 2.71U/ml),the difference was not statistically significant.Blood ca19-9 level:ascites group(79.54 ± 23.15U/ml),no ascites group(77.89 ±27.3U/ml),the difference was not statistically significant.4.The blood cea,ca125,ca19-9 and AFP levels of patients with cirrhosis were compared with those of AST normal group and AST elevation group.Compared with the AST normal group(171.73 ±135.92U/ml),the difference was statistically significant(p<0.05):the normal group of AST(59.37± 17.92ng/ml),the AST elevation group(60.62± 17.3ng/ml),the difference was not statistically significant(p>0.05).Blood CEA level:AST normal group(5.93 plus or minus 1.779 U/ml),the AST elevation group(5.46 ± 1.67U/ml),the difference was not statistically significant(p BBB 0 0.05).Serum ca19-9 level:AST normal group(79.9 ± 20.3U/ml),AST elevation group(82.1 ± 17.3U/ml),the difference was not statistically significant(p>0.05).5.Blood cea,ca125,ca19-9 and AFP levels of patients with cirrhosis were compared with those of ALP group.The ALP elevation group ca125(285.26 ± 129.53U/ml)was higher than that in the normal group of ALP(191.63 ± 115.76U/ml),and the difference was statistically significant(p<0.05).The serum AFP level:ALP normal group(70.41 ± 25.32ng/ml),and the ALP elevation group(68.62±19.3ng/ml),the difference was not statistically significant(p>0.05).Blood CEA level:ALP normal group(6.13 ± 2.0U/ml),ALP elevation group(5.79 ±1.37U/ml),the difference was not statistically significant(p>0.05).Blood ca19-9 level:ALP normal group(81.23 ± 16.65U/ml),ALP elevation group(82.67 ± 18.6U/ml),the difference was not statistically significant(p>0.05).1.Comparison of tumor markers cea,ca125,ca19-9 and AFP levels in patients with liver cancer and cirrhosis.Ca125(265.9 ±116.72U/ml)of liver cancer group was higher than that of liver cirrhosis(185.72 ± 125.36U/ml),and the difference was statistically significant(p<0.05).AFP(2236.95 ± 400.61ng/ml)was significantly higher than that of liver cirrhosis(110.97± 32.59ng/ml),and the difference was statistically significant(p<0.01).The difference of cal9-9(90.26 ± 36.72U/ml)in HCC group was higher than that in cirrhosis group(50.96 ±19.63U/ml)(p<0.05).The CEA(10.2 ± 2.52U/ml)of liver cancer group was higher than that of liver cirrhosis(3.82 ±1.91U/ml),and the difference was statistically significant(p<0.05).[Conclusions]1.CEA.Ca125.Ca199 has a certain relationship with cirrhotic liver function reserve.2.Ca125 is related to the degree of liver function damage.3.Ca125 is associated with presence of ascites.4.The joint test of ca125 and cea is helpful for the differential diagnosis of liver cirrhosis and liver cancer.5.Serum tumor markers have certain predictive value for the progression of cirrhosis.